About this Research Topic
The One Health approach (World Health Organization) integrates human and environmental health to improve sustainable health management. In the fields of toxicogenomics and ecotoxicogenomics, this approach promises numerous mutual advantages, including time and cost savings as well as a reduction of animal tests required for hazard and risk assessment. OMICs technologies enable researchers of both disciplines to identify molecular responses to stressors in a highly comprehensive manner. These can inform cross-species Adverse Outcome Pathways (AOPs), allowing for a translation of human risk to the environment and vice versa. While OMICs data pose an opportunity for pre-regulatory screening development, with prospect of an ab initio sustainable substance development, the design and assessment of OMICs studies still needs to overcome a number of challenges in order to receive acceptance by regulatory authorities.
We welcome contributions including, but not limited to the following subjects:
1) OMICs approaches in human and/or environmental hazard and risk assessment
2) Multi-OMICs interrogation of chemically induced stress responses
3) Comparison of species to species differences in chemically-affected molecular responses
4) OMICs approaches in cross-species AOP development
5) Utilisation of OMICs in the development of quantitative AOPs for regulatory applications
6) Opportunities and challenges of OMICs approaches in regulatory hazard and risk assessment
Being aware of the novelty of the approach, we explicitly encourage researchers of the above-mentioned disciplines to discuss their results in view of the One Health perspective.
Keywords: human, environmental, hazard, risk, One health, toxicogenomics, omics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.