Research Topic

Tetrel Bonding, Pnictogen Bonding and Chalcogen Bonding Interactions

About this Research Topic

A covalently bonded atom involving an element in group IV, V, or VI in an organic molecule may possess electrophilic features due to the presence of a region of positive molecular-surface electrostatic potential around the outer region of the atom (such as a covalently bonded halogen atom) called the σ-hole. This allows the atom to serve as an electron acceptor when it interacts with the electronegative atom or group. Depending on the element group, these types of intermolecular interactions are referred to as tetrel bonding, pnictogen bonding, and chalcogen bonding, respectively.

These intermolecular interactions have attracted great interest both experimentally and theoretically. Substantial experimental efforts have been devoted to finding applications in crystal engineering, materials science, organic synthesis, organocatalysis, biomedicine, drug design, etc. In addition, many theoretical studies have sought to unravel the fundamental nature of these types of intermolecular interactions by constructing different interacting systems or complexes. Additionally, many theories including energy decomposition analysis, natural bond orbital analysis, quantum theory of atoms in molecules, noncovalent interaction analysis, or symmetry adapted perturbation theory, have been used to reveal their properties. Particularly hot topics related to tetrel bonding, pnictogen bonding, and chalcogen bonding interactions, as well as others, are focused on the competition and cooperativity between different intermolecular interactions and how to quantify them.

As such, this Research Topic deals with intermolecular tetrel bonding, pnictogen bonding, and chalcogen bonding interactions as well as their competition and cooperativity. This Research Topic will present recent advances and provide a better understanding of intermolecular tetrel bonding, pnictogen bonding, and chalcogen bonding interactions. Both experimental and theoretical investigations are welcome in the form of Original Research, Mini-Review, or Perspective articles. Subjects of interest include, but are not limited to:

 • Design and development of new drugs and crystal materials via tetrel bonding, pnictogen bonding, and chalcogen bonding interactions
 • Tetrel bonding, pnictogen bonding, and chalcogen bonding interactions formed between catalyst and reactants, and their roles in organocatalysis
 • Competition and cooperativity existing in tetrel bonding, pnictogen bonding, and chalcogen bonding interactions or other intermolecular interactions, and how to quantify them
 • Novel methods based on tetrel bonding, pnictogen bonding, and chalcogen bonding interactions for understanding recognition mechanisms in chemical and biological molecules
 • Computational studies on different interacting systems involving tetrel bonding, pnictogen bonding, and chalcogen bonding, especially systems containing more than one of these


Keywords: Tetrel bonding, Pnictogen bonding, Chalcogen bonding, Weak interaction, Noncovalent interaction


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

A covalently bonded atom involving an element in group IV, V, or VI in an organic molecule may possess electrophilic features due to the presence of a region of positive molecular-surface electrostatic potential around the outer region of the atom (such as a covalently bonded halogen atom) called the σ-hole. This allows the atom to serve as an electron acceptor when it interacts with the electronegative atom or group. Depending on the element group, these types of intermolecular interactions are referred to as tetrel bonding, pnictogen bonding, and chalcogen bonding, respectively.

These intermolecular interactions have attracted great interest both experimentally and theoretically. Substantial experimental efforts have been devoted to finding applications in crystal engineering, materials science, organic synthesis, organocatalysis, biomedicine, drug design, etc. In addition, many theoretical studies have sought to unravel the fundamental nature of these types of intermolecular interactions by constructing different interacting systems or complexes. Additionally, many theories including energy decomposition analysis, natural bond orbital analysis, quantum theory of atoms in molecules, noncovalent interaction analysis, or symmetry adapted perturbation theory, have been used to reveal their properties. Particularly hot topics related to tetrel bonding, pnictogen bonding, and chalcogen bonding interactions, as well as others, are focused on the competition and cooperativity between different intermolecular interactions and how to quantify them.

As such, this Research Topic deals with intermolecular tetrel bonding, pnictogen bonding, and chalcogen bonding interactions as well as their competition and cooperativity. This Research Topic will present recent advances and provide a better understanding of intermolecular tetrel bonding, pnictogen bonding, and chalcogen bonding interactions. Both experimental and theoretical investigations are welcome in the form of Original Research, Mini-Review, or Perspective articles. Subjects of interest include, but are not limited to:

 • Design and development of new drugs and crystal materials via tetrel bonding, pnictogen bonding, and chalcogen bonding interactions
 • Tetrel bonding, pnictogen bonding, and chalcogen bonding interactions formed between catalyst and reactants, and their roles in organocatalysis
 • Competition and cooperativity existing in tetrel bonding, pnictogen bonding, and chalcogen bonding interactions or other intermolecular interactions, and how to quantify them
 • Novel methods based on tetrel bonding, pnictogen bonding, and chalcogen bonding interactions for understanding recognition mechanisms in chemical and biological molecules
 • Computational studies on different interacting systems involving tetrel bonding, pnictogen bonding, and chalcogen bonding, especially systems containing more than one of these


Keywords: Tetrel bonding, Pnictogen bonding, Chalcogen bonding, Weak interaction, Noncovalent interaction


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

21 December 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

21 December 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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