About this Research Topic
Despite great progresses in the field of oncology since the introduction of targeted therapies, including the more recent development of immunotherapies, cancers still represent a major cause of disease-related death, taking the lives of millions of people worldwide. Therefore, there is an urgent need for novel drugs and treatment strategies based on better understanding of the mechanisms that drive cancer biology. CRISPR/Cas9 is a powerful, revolutionary, genome engineering technology with a potential of applications in virtually all fields of cancer research. Especially in elucidating novel mechanisms of tumorigenesis, metastasis and treatment response eventually leading to the translation of these previously unknown discoveries into new and improved therapeutic strategies.
In this Research Topic, we welcome Original Research articles that applied CRISPR/Cas9 technology to significantly advance our understanding of basic cancer research and therapy. Topics covered may include, but are not limited to:
1. Insights on the key determinants underlying the most lethal features of cancers, like tumor initiation, growth, metastasis, resistance to chemo-, radio- and immunotherapy.
2. Groundbreaking advances in the knowledge of basic cancer biology using cancer-relevant cellular models (2D or 3D), with a particular focus on those dissecting the interplay between cancer and stromal cells in the tumor-microenvironment.
3. Novel fundamental discoveries using CRISPR/Cas9-based in vivo cancer models
4. The application of CRISPR/Cas9-based whole genome screening platforms in cancer research.
5. Application of novel CRISPR/Cas systems for systematic therapy of cancer.
A selected number of Review articles will also be considered for publication, giving higher priority to those focusing on the opportunities and challenges in the application of the CRISPR/Cas9 technologies in oncology.
Keywords: CRISPR/Cas9, cancer, mouse models, screening technologies, oncology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.