About this Research Topic
The rapid spread of multidrug-resistant (MDR) organisms constitutes one of the most significant challenges to global health. The evolution towards MDR, including its genetics and epidemiology, is still poorly understood. It may involve horizontal gene transfer (HGT), genetic mutations, clonal expansion, and other mechanisms. Bioinformatic tools such as phylogenetic network analysis, cluster analysis, comparative genomics and others can be used to analyse the evolution of MDR bacteria and fungi.
This Research Topic aims to discuss the latest advances, obtained from different countries and regions, in the evolution of MDR in clinically important bacteria and fungi, such as Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans and others. We are expecting to uncover dominant or representative MDR clones circulating in different geographic locations and reveal the extent of their chromosomal and extrachromosomal diversity and evolution. The topic, therefore, will contribute to a deeper understanding of evolutionary changes in MDR pathogens and aid the development of better detection and typing methods.
We welcome submissions of manuscripts in all acceptable formats, including original research, reviews and mini-reviews, methods and others, that present the current advances in understanding of evolution of clinically important MDR bacteria and fungi. Relevant topics of interest include (but are not limited to):
• Evolution and epidemiology of clinically relevant MDR bacteria and fungi in different countries;
• Genetic and epidemiological evolution in drug-resistance and species typing;
• Genetic diversity of pathogenic bacteria and fungi under different environmental pressure, including nosocomial and community dissemination;
• Biological characterisation of MDR pathogenic microorganisms, including virulence, persistence, fitness, competitiveness, and other characteristics;
• Molecular mechanisms contributing to the evolution of MDR pathogenic microorganisms;
• Identification of factors contributing to the expansion of pathogenic microorganisms.
Keywords: evolution, multidrug-resistance, bacteria, fungi
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.