About this Research Topic
Many transmissible viral diseases, such as foot-and-mouth disease, blue-tongue disease, vesicular stomatitis, classical swine fever or African swine fever, affect livestock and wild animals worldwide, and incur severe detrimental economic impacts globally. Livestock production employs at least 1.3 billion people worldwide, and approximately 600 million of the world's poorest households keep livestock as an essential source of income. Alongside global development, meat and milk production and consumption has increased around 40% within the last decade. Furthermore, a large proportion of recent emerging diseases have an animal origin, and almost all of them are zoonotic.
The innate immune response is the first line of defense against viral infections. Pathogen sensing by host-cell pattern recognition receptors (PRRs) triggers a signaling cascade, which results in the production and secretion of interferons (IFNs). IFNs are critical for shaping adaptive immunity, as they trigger transcription of several IFN-stimulated genes (ISGs) that incite an immune response against viral infections. Viruses have evolved different mechanisms to evade the IFN response, allowing them to spread within the host. However, viral evasion can cause hyper-induction of IFN, inducing extreme inflammatory responses. A balance between the size and timing of the IFN response is essential in controlling disease severity. Furthermore, using IFN has proven efficient for the rapid control of viral diseases in the absence of an adaptive immune response. Expanding our knowledge of agricultural viral diseases and, in particular, the role of IFN in the progression and control of these diseases is crucial in maintaining economically viable agriculture.
This Research Topic welcomes Original Research, Perspective and Review articles covering the role of IFN in agriculture viral disease and infection, particularly:
• The role of IFN in viral infection mechanisms
• The role of IFN in adaptive immune responses to viruses
• Application of IFN in virus control and treatment
Keywords: IFN, innate immunity, livestock viruses, agriculture
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.