Research Topic

Biomaterials for Vital Pulp Therapy

About this Research Topic

With the re-emergence of biologically-based procedures within the field of endodontics, understanding the underlying mechanisms involved in the tissue repair process and highlighting the implications and outcomes of the different treatment options available becomes fundamental. As a shared characteristic, these procedures involve the use of dental biomaterials with specific biological properties to aid with the establishment of a favorable medium for tissue repair or neoformation. For instance, endodontic treatment procedures aiming to preserve pulp vitality, enclosed under the term vital pulp treatment, draw upon the reparative potential of potentially viable tissue from the dentin-pulp complex by using dental biomaterials as capping agents. Ideally, these biomaterials should express a series of biological properties in order to allow or even enhance the tissue repair process i.e. ionic release and interchange, formation of a mineral attachment, antibacterial activity… among others. As another example, regenerative endodontic procedures, often referred to as revitalization or revascularization procedures, are also based on the use of biomaterials with favorable biological properties in order to succeed. By inducing the formation of a blood clot inside the root canal after disinfection, and placement of a biomaterial as a coronal barrier, reports have described a promotion of root development and a reinforcement of the dentinal walls by the deposition of mineralized tissue. As a result, this procedure emerged as an alternative to the traditional apexification procedures for the treatment of immature permanent teeth. Altogether, the implementation of treatment procedures which rely on the intrinsic reparative mechanisms of the dentin-pulp complex and its surroundings appears to be promising. Thus, research regarding dental biomaterials and their use in such procedures has become increasingly relevant.

Accordingly, the objective of the present Research Topic is to provide an updated vision on dental biomaterials research, focusing on their biological properties and interactions to act as evidence for their potential use in vital pulp treatment procedures.

This Research Topic will focus on the biological properties of new vital pulp materials and their impact on clinical practice. Full papers of original articles, communications, and review articles are all welcome.


Keywords: biocompatibility, hydraulic materials, vital pulp therapy, biomaterials, tricalcium silicates


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

With the re-emergence of biologically-based procedures within the field of endodontics, understanding the underlying mechanisms involved in the tissue repair process and highlighting the implications and outcomes of the different treatment options available becomes fundamental. As a shared characteristic, these procedures involve the use of dental biomaterials with specific biological properties to aid with the establishment of a favorable medium for tissue repair or neoformation. For instance, endodontic treatment procedures aiming to preserve pulp vitality, enclosed under the term vital pulp treatment, draw upon the reparative potential of potentially viable tissue from the dentin-pulp complex by using dental biomaterials as capping agents. Ideally, these biomaterials should express a series of biological properties in order to allow or even enhance the tissue repair process i.e. ionic release and interchange, formation of a mineral attachment, antibacterial activity… among others. As another example, regenerative endodontic procedures, often referred to as revitalization or revascularization procedures, are also based on the use of biomaterials with favorable biological properties in order to succeed. By inducing the formation of a blood clot inside the root canal after disinfection, and placement of a biomaterial as a coronal barrier, reports have described a promotion of root development and a reinforcement of the dentinal walls by the deposition of mineralized tissue. As a result, this procedure emerged as an alternative to the traditional apexification procedures for the treatment of immature permanent teeth. Altogether, the implementation of treatment procedures which rely on the intrinsic reparative mechanisms of the dentin-pulp complex and its surroundings appears to be promising. Thus, research regarding dental biomaterials and their use in such procedures has become increasingly relevant.

Accordingly, the objective of the present Research Topic is to provide an updated vision on dental biomaterials research, focusing on their biological properties and interactions to act as evidence for their potential use in vital pulp treatment procedures.

This Research Topic will focus on the biological properties of new vital pulp materials and their impact on clinical practice. Full papers of original articles, communications, and review articles are all welcome.


Keywords: biocompatibility, hydraulic materials, vital pulp therapy, biomaterials, tricalcium silicates


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

28 September 2020 Abstract
28 February 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

28 September 2020 Abstract
28 February 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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