Research Topic

Functional Changes in Sensory Ganglia Leading to Pathological Pain, with Focus on Neuron-Glia-Immune Cell Interactions

About this Research Topic

Extensive research over the last few decades revealed an important number of modifications in the functionality of nociceptive neurons upon various types of tissue injury, with an impact on the mechanisms underlying persistent pathological pain. While numerous studies continue to expose these changes in increasing detail, recent work has brought to attention the occurrence of relevant interactions between nociceptors, satellite ganglion cells (SGCs) and various types of infiltrating immune cells within sensory ganglia. Importantly, the evidence is mounting, suggesting that such an interaction results in the synthesis and release of a variety of mediators with the capacity to alter the excitability of both injured as well as uninjured primary afferent neurons, likely contributing to persistent pain. This Research Topic aims at publishing important basic research, as well as translational and clinical findings on changes in the functionality of primary afferent neurons, under the light of neuron-glia-immune cell interactions. The scope of this Research Topic is broad, covering all scientific aspects and techniques of relevance to the field, from molecular and cellular aspects to animal models and translation into humans. Our goal is to provide a comprehensive forum through which quality research can be disseminated to a wide audience.


Keywords: Pain, Sensory Ganglion, Satellite Cell, Macrophage, Primary Neuron


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Extensive research over the last few decades revealed an important number of modifications in the functionality of nociceptive neurons upon various types of tissue injury, with an impact on the mechanisms underlying persistent pathological pain. While numerous studies continue to expose these changes in increasing detail, recent work has brought to attention the occurrence of relevant interactions between nociceptors, satellite ganglion cells (SGCs) and various types of infiltrating immune cells within sensory ganglia. Importantly, the evidence is mounting, suggesting that such an interaction results in the synthesis and release of a variety of mediators with the capacity to alter the excitability of both injured as well as uninjured primary afferent neurons, likely contributing to persistent pain. This Research Topic aims at publishing important basic research, as well as translational and clinical findings on changes in the functionality of primary afferent neurons, under the light of neuron-glia-immune cell interactions. The scope of this Research Topic is broad, covering all scientific aspects and techniques of relevance to the field, from molecular and cellular aspects to animal models and translation into humans. Our goal is to provide a comprehensive forum through which quality research can be disseminated to a wide audience.


Keywords: Pain, Sensory Ganglion, Satellite Cell, Macrophage, Primary Neuron


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

18 January 2021 Abstract
30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

18 January 2021 Abstract
30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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