About this Research Topic
Extensive research over the last few decades revealed an important number of modifications in the functionality of nociceptive neurons upon various types of tissue injury, with an impact on the mechanisms underlying persistent pathological pain. While numerous studies continue to expose these changes in increasing detail, recent work has brought to attention the occurrence of relevant interactions between nociceptors, satellite ganglion cells (SGCs) and various types of infiltrating immune cells within sensory ganglia. Importantly, the evidence is mounting, suggesting that such an interaction results in the synthesis and release of a variety of mediators with the capacity to alter the excitability of both injured as well as uninjured primary afferent neurons, likely contributing to persistent pain. This Research Topic aims at publishing important basic research, as well as translational and clinical findings on changes in the functionality of primary afferent neurons, under the light of neuron-glia-immune cell interactions. The scope of this Research Topic is broad, covering all scientific aspects and techniques of relevance to the field, from molecular and cellular aspects to animal models and translation into humans. Our goal is to provide a comprehensive forum through which quality research can be disseminated to a wide audience.
Keywords: Pain, Sensory Ganglion, Satellite Cell, Macrophage, Primary Neuron
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