About this Research Topic
Metabolism is a complex phenomenon achieved by multiple organs to regulate it to the point of "Homeostasis". Among these organs/tissues, accumulated evidence suggests the central nervous system has a key role in the homeostatic regulation of metabolism. The nervous system integrates circulating nutrient availability with hormonal inputs that originate from organ systems positioned throughout the body, and coordinates fuel utilization/storage across a diverse array of organ systems necessary for physiological functions and behavior execution. The energy balance maintenance across interdependent organ systems requires complex bidirectional information sharing between each organ and a central hub. Defective central regulation of metabolism contributes to various metabolic symptoms including but not limiting to the development of obesity and type 2 diabetes.
The goal of this special edition is to explore the detailed mechanisms linking the central nervous system and the metabolic regulation, homeostasis, and associated diseases. It will also cover emerging areas such as the neuronal regulation of peripheral metabolic functions.
This Special Issue will focus on reviews and original data manuscripts that concern:
(1) Neuronal mechanisms of food intake or energy expenditure associated with the central nervous system;
(2) Studies on molecular mechanisms related to central regulated thermogenesis and physical activity;
(3) Pathophysiology of the metabolic central regulation;
(4) New molecular targets for the central regulation of peripheral metabolic functions;
(5) Dysfunction of peripheral organs with an associated change in behavior and circulating hormonal profile or metabolic phenotype;
(6) Adaptation of the central nervous system related to a change in hormones profile associated with energy balance perturbations;
(7) Genetic or cellular manipulations to the central nervous system that result in changes to the whole body energy balance;
(8) Behavioral strategies to improve whole body energy balance.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.