About this Research Topic
Viscoelasticity is influenced by energy transfer and dissipation during cell rearrangements at various time and space scales. Cumulative effects of structural changes at subcellular and cellular levels influence viscoelastic response at a supracellular level.
Tissue viscoelasticity characterizes its fluidity and has strong effects on various biological processes such as morphogenesis, migration, tissue repair and cancer metastasis. In turn, altered cellular viscoelasticity is a strong indicator of diseases including cancer, infection, and aging.
It is thus becoming crucial to properly calibrate stress-strain relations with novel experimental measurements, and to relate them within the underlying biochemical and biomechanical processes.
This Research Topic aims at bridging the macroscopic viscoelastic parameters with the individual and collective cell response. Critical consideration of biochemical, biophysical and bio mechanical aspects leading to tissue remodeling intercalation or migration, and how these phenomena are influenced by the viscoelastic properties will be discussed on various multicellular systems under in vivo and in vitro conditions. Alternative techniques to measure and control cell rearrangement under various experimental conditions will be also considered.
In this Research Topic we would like to focus on how viscoelasticity at various scales intervenes in collective cellular phenomena such as tissue remodeling and collective cell migration observed in various morphological and disease propagation processes. Topics include:
• Biochemical, biophysical and biomechanical aspects in tissue remodeling.
• Stress relaxation in multicellular systems in vivo and in vitro.
• Modeling techniques of tissue viscoelasticity.
• Experimental techniques to measure tissue viscoelasticity in vivo and ex vivo.
• Rheological models for cell and tissue mechanics.
Keywords: collective migration, rheology, cell mechanics, tissue stress, molecular processes
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