Research Topic

Nanoparticles as Advanced Enzyme Delivery Systems for Therapeutic Applications

About this Research Topic

Nanoparticles have drawn tremendous attention in recent decades due to their superior physical and chemical properties, small size, and surface-to-mass ratio over their counterparts. Due to these unique characteristics, as well as their ability to interact with cells/tissues, much effort has been devoted to the immobilization and specific delivery of various molecules for biomedical applications such as drug delivery and tissue engineering. Until recently, most research has been focused on small molecules/drugs as therapeutic or imaging agents, with unexpectedly positive results. However, experimental studies for the interaction and subsequent delivery of bigger molecules such as proteins, including enzymes on different types of nanocarriers, have formed a new research area with great potential in the field of targeted delivery and therapeutic biochemistry. Enzymes offer a series of key properties compared to conventional drugs, such as high activity and selectivity when binding and acting on their targets, precise targeting, protection against oxidative stress and inflammation, and excellent catalytic properties.

All of these properties of enzymes may be overshadowed by undesired side effects, high toxicity, and aggregation phenomena, which can lead to high risk effects. As such, this Research Topic focuses on the synthesis of innovative nanoparticles that can interact efficiently with different types of enzymes, studying the mechanisms of release and delivery to specific tissues.

We welcome the submission of experimental and theoretical Original Research and Review articles on themes including, but not limited to:

 • Synthesis, characterization and study of properties of different types of novel nanoparticles (carbon based, inorganic, organic, mesoporous, etc)
 • Studies on the mechanism of release and delivery of the enzymes to specific tissues
 • Potential applications for enzyme carrier nanostructures
 • Studies of naturally occurring nanoparticles that could be used in enzyme delivery applications


Keywords: nanoparticles, enzyme delivery, characterization, nanostructures, release, therapeutic applications


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Nanoparticles have drawn tremendous attention in recent decades due to their superior physical and chemical properties, small size, and surface-to-mass ratio over their counterparts. Due to these unique characteristics, as well as their ability to interact with cells/tissues, much effort has been devoted to the immobilization and specific delivery of various molecules for biomedical applications such as drug delivery and tissue engineering. Until recently, most research has been focused on small molecules/drugs as therapeutic or imaging agents, with unexpectedly positive results. However, experimental studies for the interaction and subsequent delivery of bigger molecules such as proteins, including enzymes on different types of nanocarriers, have formed a new research area with great potential in the field of targeted delivery and therapeutic biochemistry. Enzymes offer a series of key properties compared to conventional drugs, such as high activity and selectivity when binding and acting on their targets, precise targeting, protection against oxidative stress and inflammation, and excellent catalytic properties.

All of these properties of enzymes may be overshadowed by undesired side effects, high toxicity, and aggregation phenomena, which can lead to high risk effects. As such, this Research Topic focuses on the synthesis of innovative nanoparticles that can interact efficiently with different types of enzymes, studying the mechanisms of release and delivery to specific tissues.

We welcome the submission of experimental and theoretical Original Research and Review articles on themes including, but not limited to:

 • Synthesis, characterization and study of properties of different types of novel nanoparticles (carbon based, inorganic, organic, mesoporous, etc)
 • Studies on the mechanism of release and delivery of the enzymes to specific tissues
 • Potential applications for enzyme carrier nanostructures
 • Studies of naturally occurring nanoparticles that could be used in enzyme delivery applications


Keywords: nanoparticles, enzyme delivery, characterization, nanostructures, release, therapeutic applications


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

08 January 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

08 January 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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