About this Research Topic
Warburg effect is the best characterized metabolic phenotype in tumor cells. To meet the increased anabolic needs of proliferation, cancer cells require both sufficient energy and biosynthetic precursors as cellular building blocks to support cell survival and growth. Cancer cells metabolize glucose by aerobic glycolysis (Warburg effect) rather than through the more energetically efficient oxidative phosphorylation (OXPHOS) even in the presence of oxygen. With relatively poor efficiency of generating ATP, Warburg effect still allows the switch of glycolytic intermediates into various biosynthetic pathways, which in turn facilitate the biosynthesis of macromolecules that are required for assembling new cells. Accumulated evidence reveals that Warburg effect contributes to the progression of hepatobiliary and pancreatic cancer. However, exact role and molecular mechanisms of Warburg effect in hepatobiliary and pancreatic cancer are still unknown.
The first objective of this Research Topic is to unveil the role and mechanisms of Warburg effect in the development, growth, metastasis, and chemoresistance of hepatobiliary and pancreatic cancer. Additionally, because the complexity and interconnectedness of metabolic signalling, targeting a particular metabolic pathway may have limited anticancer effects. However, dampening metabolic flexibility of cancer cells by targeting master regulators can make them more sensitive to cytotoxic chemotherapy. As drugs that target the known master regulators such as the MAPK and PI3K-mTOR pathways and activated oncogenes (e.g., Ras, c-Myc) show limited effects in hepatobiliary and pancreatic cancer, it is necessary to explore new master regulators of Warburg effect.
We welcome Original Research articles and Reviews on the themes below:
- The role and mechanism of Warburg effect in the development, growth, metastasis, and chemoresistance of hepatobiliary and pancreatic cancer.
- New master regulators of Warburg effect in hepatobiliary and pancreatic cancer.
- The influence of Warburg effect on epigenetics.
- The influence of Warburg effect on immune evasion.
- The role of non-coding RNA in the regulation of Warburg effect in hepatobiliary and pancreatic cancer.
- The effects of Warburg effect on specific inhibitors in hepatobiliary and pancreatic cancer.
Keywords: Warburg effect, aerobic glycolysis, hepatocellular carcinoma, cholangiocarcinoma, pancreatic cancer
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