Research Topic

New Insights into Oxidative Stress and Inflammation in the Pathophysiology and Treatment of Cardiovascular Diseases

About this Research Topic

Cardiovascular diseases (CVDs), the first cause of death globally, with 17.9 million deaths estimated each year, are gaining in prevalence worldwide. CVDs include conditions that affect the structure and function of heart and blood vessels, such coronary heart disease, peripheral arterial disease, aortic disease, cerebrovascular disease, rheumatic heart disease and other conditions. Evidence from experimental and clinical studies have shown that oxidative stress, inflammation and autophagy are closely associated with CVDs, being also reciprocally induced. Indeed, anti-inflammatory therapies have demonstrated protective effects both in models of cardiovascular disease and in large-scale clinical trials which revealed reduced cardiovascular mortality in patients with CVDs. However, the relationship between increased oxidative stress, inflammation, and autophagy deregulation in CVDs, and the molecular mechanisms underlying these alterations are not completely clarified.

We invite investigators to contribute original research articles, as well as review articles focusing on the emerging role of oxidative stress and inflammation in CVDs.
We hope that the articles published in this Research Topic will contribute to the understanding of the pathogenetic mechanisms of cardiovascular diseases, and will permit the discovery of novel specific biomarkers and the setting up of new potential therapeutic approaches for the treatment of CVDs.

Areas to be covered in this Research Topic may include, but are not limited to:

• Targeting new pathways involved in CVDs pathogenesis for diagnostic and therapeutic purposes;
• New oxidative stress biomarkers in CVDs;
• Research focused on “-omics”-based technologies used for personalized medicine;
• Pharmacological agents that modulate redox regulation in CVDs;
In vitro and in vivo studies on the role of autophagy in CVDs;
• The interplay between autophagy dis-regulation and oxidative stress damage in CVDs;
• Pharmacological and non-pharmacological approaches to modulate autophagy and ROS production including dietary interventions;
• Characterization of signalling pathways.

A list of accepted article types including descriptions can be found at this link.


Keywords: Cardiovascular Diseases, Antioxidants, Signaling pathways, Biomarkers, Oxidative Stress, Autophagy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Cardiovascular diseases (CVDs), the first cause of death globally, with 17.9 million deaths estimated each year, are gaining in prevalence worldwide. CVDs include conditions that affect the structure and function of heart and blood vessels, such coronary heart disease, peripheral arterial disease, aortic disease, cerebrovascular disease, rheumatic heart disease and other conditions. Evidence from experimental and clinical studies have shown that oxidative stress, inflammation and autophagy are closely associated with CVDs, being also reciprocally induced. Indeed, anti-inflammatory therapies have demonstrated protective effects both in models of cardiovascular disease and in large-scale clinical trials which revealed reduced cardiovascular mortality in patients with CVDs. However, the relationship between increased oxidative stress, inflammation, and autophagy deregulation in CVDs, and the molecular mechanisms underlying these alterations are not completely clarified.

We invite investigators to contribute original research articles, as well as review articles focusing on the emerging role of oxidative stress and inflammation in CVDs.
We hope that the articles published in this Research Topic will contribute to the understanding of the pathogenetic mechanisms of cardiovascular diseases, and will permit the discovery of novel specific biomarkers and the setting up of new potential therapeutic approaches for the treatment of CVDs.

Areas to be covered in this Research Topic may include, but are not limited to:

• Targeting new pathways involved in CVDs pathogenesis for diagnostic and therapeutic purposes;
• New oxidative stress biomarkers in CVDs;
• Research focused on “-omics”-based technologies used for personalized medicine;
• Pharmacological agents that modulate redox regulation in CVDs;
In vitro and in vivo studies on the role of autophagy in CVDs;
• The interplay between autophagy dis-regulation and oxidative stress damage in CVDs;
• Pharmacological and non-pharmacological approaches to modulate autophagy and ROS production including dietary interventions;
• Characterization of signalling pathways.

A list of accepted article types including descriptions can be found at this link.


Keywords: Cardiovascular Diseases, Antioxidants, Signaling pathways, Biomarkers, Oxidative Stress, Autophagy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

09 January 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

09 January 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..