About this Research Topic
Colorectal cancer (CRC) represents one of the most prevalent malignancies and is a major cause of cancer-related death. However, only a small number of CRC cases are due to inherited gene mutations. The overwhelming majority of CRC cases is a result of a life-long accumulation of genetic alterations. Lifestyle and environmental causes - dietary habits in particular - are known to play a significant role in CRC development.
In this context, we propose a Research Topic around the theme of nutrition and colorectal cancer. We encourage submissions of Original Research and Review articles including mechanistic, translational and clinical research focusing on the following topics:
1. Diet and CRC prevention
- Effects of diet on DNA damage and DNA repair induction
- Epigenetic effects of dietary constituents
- Phytochemicals and oxidative stress defenses
- Novel foods with anti-CRC properties
2. Diet and CRC management
- Effects of diet on promotion and progression phases of tumor development
- Signaling pathways of cell proliferation (cell cycle), differentiation, migration or cell death
- Synergistic effects diet/chemotherapeutic agent
- Dietary strategies for the prevention of cachexia
- Medical foods, pharmaconutrition in CRC patients
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
