Research Topic

Nano-Based Improvements of Bioactive Compound Pharmacological Properties for the Treatment of Alzheimer's Disease and Parkinson's Disease

About this Research Topic

Neurological diseases affect close to a billion people around the world. These types of disorders are mostly related to age and degeneration. So, with the growth of mean life expectancy, it is also expected that levels of this type of disease will increase and become a devastating global health issue. Some neurological diseases still have no cure, such as Alzheimer’s disease (AD), that already affects more than 46 million patients, and Parkinson’s disease (PD), the second most common neurodegenerative disease after AD. A promising approach for this range of neurological diseases is the use of natural compounds (NCs) that have an extensive spectrum of action. Several compounds with pharmacological activities isolated from plants, animals, and microorganisms been have been reported to be beneficial in clinical trials. So, in recent years, bioactive compounds have aroused interest, not only in the research community but also with pharmaceutical companies. However, the use of bioactive compounds present several limitations, mainly related to bioavailability and their limited ability to reach the brain area.

Over the last decade, several strategies have been proposed to bypass these bioactive compound limitations. Several strategies could be applied, such as chemical modifications of the molecules. But one of the most promising strategies is related to the encapsulation of those compounds in carriers of several natures, such as polymers or lipids. Nanocarriers could have the ability to cross the brain, protecting the bioactive compounds from degradation, and allow them to reach the affected area in therapeutic concentrations without modifying the compound’s physicochemical properties. With this Research Topic we expect to make a compilation of the most pioneering strategies to improve the bioactive compound's therapeutic effects for treating Alzheimer's and Parkinson's.

This Research Topic welcomes Original Research and Review papers on the following topics, for the treatment of Alzheimer’s and Parkinson’s:

• Chemical modifications of natural compounds to increase their bioavailability in the brain
• Emerging trends of nanocarriers to transport bioactive compounds to the brain
• Modulation of bioactive compounds to cross the blood-brain barrier

Important Note: All submissions/contributions to this Research Topic must be in line with the scope of the journal/section they are submitted to. While authors are encouraged to draw from other disciplines to enrich their papers where relevant, they must ensure papers fall within the scope of the journal/section, as expressed in its mission statement.


Keywords: Emerging Therapies, Neurological Disease Treatments, Nanocarriers, Nanobiotechnology, Biodrug Delivery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Neurological diseases affect close to a billion people around the world. These types of disorders are mostly related to age and degeneration. So, with the growth of mean life expectancy, it is also expected that levels of this type of disease will increase and become a devastating global health issue. Some neurological diseases still have no cure, such as Alzheimer’s disease (AD), that already affects more than 46 million patients, and Parkinson’s disease (PD), the second most common neurodegenerative disease after AD. A promising approach for this range of neurological diseases is the use of natural compounds (NCs) that have an extensive spectrum of action. Several compounds with pharmacological activities isolated from plants, animals, and microorganisms been have been reported to be beneficial in clinical trials. So, in recent years, bioactive compounds have aroused interest, not only in the research community but also with pharmaceutical companies. However, the use of bioactive compounds present several limitations, mainly related to bioavailability and their limited ability to reach the brain area.

Over the last decade, several strategies have been proposed to bypass these bioactive compound limitations. Several strategies could be applied, such as chemical modifications of the molecules. But one of the most promising strategies is related to the encapsulation of those compounds in carriers of several natures, such as polymers or lipids. Nanocarriers could have the ability to cross the brain, protecting the bioactive compounds from degradation, and allow them to reach the affected area in therapeutic concentrations without modifying the compound’s physicochemical properties. With this Research Topic we expect to make a compilation of the most pioneering strategies to improve the bioactive compound's therapeutic effects for treating Alzheimer's and Parkinson's.

This Research Topic welcomes Original Research and Review papers on the following topics, for the treatment of Alzheimer’s and Parkinson’s:

• Chemical modifications of natural compounds to increase their bioavailability in the brain
• Emerging trends of nanocarriers to transport bioactive compounds to the brain
• Modulation of bioactive compounds to cross the blood-brain barrier

Important Note: All submissions/contributions to this Research Topic must be in line with the scope of the journal/section they are submitted to. While authors are encouraged to draw from other disciplines to enrich their papers where relevant, they must ensure papers fall within the scope of the journal/section, as expressed in its mission statement.


Keywords: Emerging Therapies, Neurological Disease Treatments, Nanocarriers, Nanobiotechnology, Biodrug Delivery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

16 January 2021 Manuscript
15 February 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

16 January 2021 Manuscript
15 February 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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