About this Research Topic
Bioprinting is a three-dimensional (3D) fabrication technology used to accurately dispense cell-laden biomaterials for the fabrication of complex and native 3D functional living tissues. While advances have been made in this field with the introduction of advanced bioprinter devices, there is still significant variability in structural and functional characteristics of bioprinted tissues depending on the biomaterials used. Biomaterials used as bioinks for bioprinting should exhibit stability and non-cytotoxicity by supporting cell viability as a function of biocompatibility. Although major progress has been made with both natural and synthetic hydrogels in bioprinting, there are still significant complications with bioinks in regard to the required physical and biological properties in mimicking real tissues. Many biomimetic materials often lack the mechanical strength to be the sole material in printed tissues, and tunable bioinks with a wide range of material properties could be a possible approach through the creation of new composite mixtures.
Papers are sought in areas that addresses development of bioink for large 3D constructs that replicate a certain degree of tissue organization needed for translation of bioprinted tissue towards clinical application, use of metamaterials that can be used to tweak the mechanical behavior of the printed constructs, bioinks that improves vascularization of tissue constructs, differential graded bioinks for regulated and systemic degradation due to cellular proliferation, viscoelastic function of bioink for regulating structural and biological integrity of the printed materials, enforcing microenvironmental niche for bioprinting, real-time monitoring of biological features of the printing bioink, differentially compressed bioink to print differential density of cell spatially, bioprinting ensuring micro-niche for neurovascular integration within the printed cellular construct, bioprinting over microfluidic platform, bioprinting conserving micro-patterning.
Keywords: Bioink, 3D Bioprinting, Smart Materials, Metamaterials, Tissue Constructs, Vascularization
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