About this Research Topic
The metabolome is composed of chemically diverse metabolites that dramatically vary in their abundance. The broad dynamic range and chemical complexity represent significant challenges in metabolomics. Multi-dimensional separation techniques and complex instrumental ensembles are needed to increase the separation power and resolution. These include multi-dimensional chromatographic and ion mobility separations, as well as complex instrumental ensembles such as UHPLC-MS-NMR.
This Research Topic is intended to highlight recent research trends in multi-dimensional separations and/or complex instrumental ensembles to advance the utility and coverage of metabolomics. Areas to be covered include:
- Technology development (e.g. multi-dimensional chromatographic separations (LCxLC, GCxGC), xC-ion mobility separations, xC-MS-NMR, etc.);
- Multi-dimensional separations coupled to high-resolution MS metabolomics strategies and techniques;
- Application of multi-dimensional separation technologies in metabolomics that advance our metabolic understanding of complex biological systems and samples;
- New method developments in multi-dimensional chromatographic separations;
- Computational methods to improve the prediction or interpretation of CCS values, retention times or retention indices.
Both original research as well as review articles will be accepted for this Research Topic. The manuscripts should cover one or more of the following themes:
• Ion mobility separation of isobaric compounds to increase metabolite coverage breadth;
• Ion mobility database generation (e.g. CCS data library, CCS prediction, CCS modeling);
• Two-dimensional chromatographic separations in metabolomics;
• New methods for detection of quantification of specialized metabolites (e.g. methods for glycan analysis, bile acid analysis, organic acid analysis, etc.);
• Metabolite identification using multi-dimensional separations and complex instrumental ensembles;
• Retention time or retention index prediction/modeling to assist with compound identification.
A list of accepted article types including descriptions can be found at this link.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.