Research Topic

Vascular Effects of Oncological Treatments: from Pathophysiology to Vascular Protection

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About this Research Topic

Several cancer therapies designed to interfere with a specific molecular pathway have been associated with a broad spectrum of vascular toxicities, ranging from progressive atherosclerosis to acute vascular events, and both arterial stenosis and venous thrombosis. Furthermore, drugs targeting the vascular ...

Several cancer therapies designed to interfere with a specific molecular pathway have been associated with a broad spectrum of vascular toxicities, ranging from progressive atherosclerosis to acute vascular events, and both arterial stenosis and venous thrombosis. Furthermore, drugs targeting the vascular growth factor signaling pathway have been associated with new-onset or worsening of systemic hypertension. The exact pathophysiological mechanisms underlying these manifestations of toxicity have been poorly investigated. From a clinical standpoint, early detection of vascular toxicity may be extremely important in order to start the proper treatment and allow the patient to continue chemotherapy. Finally, strategies aimed at preventing the development of such side effects are lacking.

This Research Topic is dedicated at gathering the latest knowledge about the following topics: 1) pathophysiological mechanisms that are involved in the development of vascular manifestation of different chemotherapeutic treatments; 2) usefulness of screening tools for early diagnosis of vascular alterations in oncological patients treated with chemotherapies with potential vascular toxicity; chemotherapies; 3) development of programs of vascular protection in this setting.
Translational contributions are also welcome.

• Pathophysiological mechanisms of chemotherapy-induced vascular toxicity
• Role of serological, imaging and functional biomarkers in the stratification of cardiovascular risk of patients undergoing chemotherapies with potential vascular toxicity
• Role of serological, imaging and functional biomarkers in the early detection of chemotherapy-induced vascular toxicity
• Proposals for recommendations for clinical and instrumental monitoring of chemotherapy-induced vascular toxicity


Keywords: Vascular toxicity, oncological treatments, vascular pathophysiology, vascular protection


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