Research Topic

Primary Preventative Mechanisms in Pediatric Allergy and Asthma

About this Research Topic

The prevalence of allergy and asthma have been growing in recent years in industrialized countries. Multiple and, to a great extent, unknown interactions between genetic and environmental factors are surely beyond that fact. At the same time, the knowledge about the intrinsic mechanisms leading to the development of allergies and asthma has enormously increased throughout the last decades. Thus, a considerable body of evidence illustrating the importance of several “omics” in this respect (metabolomics, proteomics, microbiomics, epigenomics, transcriptomics…) is being constantly generated.

Then, the possibility to successfully intervene in early phases of the allergic disease or even before its beginning, seems not to be a chimera in the medium term. However, the complexity and variability in relation to multiple underlying pheno-endotypes in allergy and asthma, as well as the possibility that uncountable environmental factors can have a decisive role in this respect, adds an extreme difficulty to the issue. Nevertheless, the use of supervised and unsupervised machine-learning approaches based on pattern recognition computer algorithms could decisively contribute to unravel the complexity and variability in relation to multiple underlying pheno-endotypes in allergy and asthma.

This would provide a more robust foundation to newly growing paradigm based on the “personalized medicine”, since this strategy would permit more precise, safe and tailored preventative and therapeutic actions for each individual. This research topic welcomes submissions of all article types related to these primary preventative mechanisms in pediatric allergy and asthma.


Keywords: Asthma, Allergy, primary prevention, omics, personalised medicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The prevalence of allergy and asthma have been growing in recent years in industrialized countries. Multiple and, to a great extent, unknown interactions between genetic and environmental factors are surely beyond that fact. At the same time, the knowledge about the intrinsic mechanisms leading to the development of allergies and asthma has enormously increased throughout the last decades. Thus, a considerable body of evidence illustrating the importance of several “omics” in this respect (metabolomics, proteomics, microbiomics, epigenomics, transcriptomics…) is being constantly generated.

Then, the possibility to successfully intervene in early phases of the allergic disease or even before its beginning, seems not to be a chimera in the medium term. However, the complexity and variability in relation to multiple underlying pheno-endotypes in allergy and asthma, as well as the possibility that uncountable environmental factors can have a decisive role in this respect, adds an extreme difficulty to the issue. Nevertheless, the use of supervised and unsupervised machine-learning approaches based on pattern recognition computer algorithms could decisively contribute to unravel the complexity and variability in relation to multiple underlying pheno-endotypes in allergy and asthma.

This would provide a more robust foundation to newly growing paradigm based on the “personalized medicine”, since this strategy would permit more precise, safe and tailored preventative and therapeutic actions for each individual. This research topic welcomes submissions of all article types related to these primary preventative mechanisms in pediatric allergy and asthma.


Keywords: Asthma, Allergy, primary prevention, omics, personalised medicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

07 November 2020 Abstract
07 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

07 November 2020 Abstract
07 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..