About this Research Topic
Neuropsychiatric diseases are complex diseases and intimately related to changes in the brain over time. It is generally accepted that the risk of developing such diseases depends on both environmental and genetical factors. Last decade witnessed a tremendous success of the Genome wide association studies (GWAS) for Neuropsychiatric diseases in discovering risk associated genetic variants. These genetic variants were shown to be involved in a wide range of biological pathways that are potentially related to the risk of developing these diseases. Previous studies have also reported large variations in the disease onset, progression and response to treatment in patients with neuropsychiatric diseases. Thus, it is important to take into account time as an extra dimension in large scale genomic studies of neuropsychiatric diseases.
The genetic compositions of individuals are largely stable over lifespan, however, the age of onset of neuropsychiatric diseases vary between individuals and diseases. In addition, non-genetic risk factors for neuropsychiatric diseases are constantly changing during lifespan. How genetic variants exert their effect on the development of neuropsychiatric disease in terms of timing is a hot research topic in the field of neurogenomics. Questions, such as “Do risk conferring genetic variants manifest their effect at specific time or influence other non-genetic risk factors for neuropsychiatric diseases throughout lifespan?” and “Are treatment response trajectories influenced by the genetic composition of patients?” has not been thoroughly studied. A gain of knowledge will help us improving disease prognosis and personalized treatment. Thus, this Research Topic focuses on studies of genetic effect on the development, progression, and treatment response of neuropsychiatric diseases.
We are aiming to collect studies integrating genomics with traditional longitudinal studies focusing on changes into brain structure or function and the development or treatment of disease. Topics of interest include the following:
• Studies of genetic impact on the age of onset of neuropsychiatric diseases.
• Studies of genetic influence on the changes of biomarkers for neuropsychiatric diseases.
• Studies of genetic impact on the treatment response trajectories for neuropsychiatric diseases.
Articles in the form of Original Research, Reviews and Perspectives related to the above topics will be considered for this Research Topic.
Keywords: Genomics, Brain changes, Neuropsychiatry, Longitudinal analysis
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