Research Topic

Interdisciplinary Cooperation Converts Natural Products into Drug Candidates

About this Research Topic

New drug development is an interdisciplinary endeavour that relies on the cooperation between pharmacology, pharmaceutical chemistry, pharmaceutical analysis, and pharmacy. Generally, the identification of disease-related targets is the first step in drug discovery and development, requiring the knowledge from epidemiology, genomics, structural biology and system biology. This step could give the researcher a better understanding of the disease to be treated, and help the researcher to build a hypothesis that how to influence the structure of the disease-related target and to obtain the desired function. Following that, the researcher should perform lead compound discovery and optimization to confirm the hypothesis and find the potential candidate. In this process, various kinds of laboratory tests and experiments, including experiments in silico, in vitro, in vivo were involved.

Natural products are the primary source of clinically used drugs. However, their characteristics of multi-targets may cause problems in the target identification and validation which should be enhanced. Besides, how to improve the bioavailability of natural products is another question that should be considered. In the process of converting the bio-active hit into a drug candidate, researchers work on lead compounds discovery, target identification and validation, bioavailability improvement should make extensive cooperations. Therefore, interdisciplinary collaboration and communication are becoming more and more important and significant.

This Research Topic covers a wide range of areas such as natural products discovery, total synthesis, target identification and validation, and bioavailability improvement. However, studies carried out with crude extracts/multiherbal preparations without chemically characterized compounds and/or in silico studies without actual biological experiments are not suitable for this Topic. This collection welcomes articles covering, but not limited to the themes.
• Bioactive natural products discovery/ total synthesis/ target identification and validation
• Active compounds bioavailability improvement approaches, such as prodrug design, drug delivery system
• Interdisciplinary cooperation cases


Keywords: Interdisciplinary, Natural products, Lead compound discovery, Total synthesis, Target identification and validation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

New drug development is an interdisciplinary endeavour that relies on the cooperation between pharmacology, pharmaceutical chemistry, pharmaceutical analysis, and pharmacy. Generally, the identification of disease-related targets is the first step in drug discovery and development, requiring the knowledge from epidemiology, genomics, structural biology and system biology. This step could give the researcher a better understanding of the disease to be treated, and help the researcher to build a hypothesis that how to influence the structure of the disease-related target and to obtain the desired function. Following that, the researcher should perform lead compound discovery and optimization to confirm the hypothesis and find the potential candidate. In this process, various kinds of laboratory tests and experiments, including experiments in silico, in vitro, in vivo were involved.

Natural products are the primary source of clinically used drugs. However, their characteristics of multi-targets may cause problems in the target identification and validation which should be enhanced. Besides, how to improve the bioavailability of natural products is another question that should be considered. In the process of converting the bio-active hit into a drug candidate, researchers work on lead compounds discovery, target identification and validation, bioavailability improvement should make extensive cooperations. Therefore, interdisciplinary collaboration and communication are becoming more and more important and significant.

This Research Topic covers a wide range of areas such as natural products discovery, total synthesis, target identification and validation, and bioavailability improvement. However, studies carried out with crude extracts/multiherbal preparations without chemically characterized compounds and/or in silico studies without actual biological experiments are not suitable for this Topic. This collection welcomes articles covering, but not limited to the themes.
• Bioactive natural products discovery/ total synthesis/ target identification and validation
• Active compounds bioavailability improvement approaches, such as prodrug design, drug delivery system
• Interdisciplinary cooperation cases


Keywords: Interdisciplinary, Natural products, Lead compound discovery, Total synthesis, Target identification and validation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 November 2020 Abstract
30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 November 2020 Abstract
30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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