Research Topic

Multifunctional Nanoparticles and Nanostructured Materials as Innovative Tools for Real-Time Liquid Biopsy and Imaging

About this Research Topic

The global cancer incidence and the heterogeneity of tumors and tumor biomarkers pose a significant challenge to the human resource involved in this research area. Medical doctors and scientific researchers often gather in a common effort to develop innovative and efficient tools (drug compounds, diagnostic methods and devices) for the early detection and curing of cancer. The task becomes even harder when the investigated item (biomarker or the whole cell) is not located within a fixed spot, as is the case of non-solid tumors/non-adherent cancer cells (e.g. lymphoblasts, myeloblasts, circulating tumor cells). In this regard, nanotechnology-based approaches may come as an alternative to the complex, expensive and time-consuming current lab-methods used for the capture and identification of this specific type of cancer cells, allowing for a faster and less-laborious imaging and identification.

This Research Topic puts a spotlight on the nanotechnology-derived products (nanoparticles and nanostructured materials) that can be successfully used in combination with validated microspectroscopic techniques such as Raman, infrared (IR) or fluorescence spectroscopy, for the efficient and rapid detection of non-adherent cancer cells and associated biomarkers. The up-to- date research related to the implementation of such innovative strategies, by highlighting their strengths and limitations in comparison with validated clinical techniques, will be presented. Comprehensive overview of the origin, properties, testing and potential use of nanotechnology-related vs conventional liquid biopsy as a multimodal diagnostic and prognostic tool for the assessment of non-solid tumors is also open to discussion.

The aim of this Research Topic is to highlight promising, novel, recent and currently ongoing research on the development of nanoparticle and nanostructure-related spectroscopic tools for the real-time liquid biopsy and imaging of non-solid tumors/non-adherent cancer cells. Areas to be covered may include, but are not limited to:

• Multifunctional nanoparticles as sensitivity enhancers for cancer detection
• Nanostructured materials for non-adherent cancer cell capture and identification
• Real-time liquid biopsy in cancer: non-adherent cancer cell detection and analysis
• Micro/nano-fluidic devices for cancer biomarker detection and screening
• Nanotechnology approaches for in-flow detection of circulating tumor cells (CTCs)
• Microspectroscopic methods for the identification and classification of non-solid tumors
• Nanostructures and nanomaterials for detecting malignancy-derived nucleic acids or exosomes
• Perspectives on clinical application and translation of nano-integrated liquid biopsy techniques

Original research papers and up-to-date review articles are welcome.

Topic Editor Dr. Long-Sheng Lu has received industrial-academic collaboration grants from Cancerfree Biotech Inc., Bosomeer Biotech Inc., Unimed Inc. and Nanoray Biotech Co. Ltd. He holds 5 international patents with regards to cancer radiotherapy and precision cancer medicine. Dr. Dana Cialla-May holds 3 patents regarding method for identifying viruses, surface reinforcing plasmonic substrate and Activated 3-D nano surface, process for its production and its use. The other Topic Editors declare no competing interests regarding the Research Topic subject.


Keywords: Nanoparticles, Nanostructures, Liquid Biopsy, Spectroscopic Imaging, Microspectroscopy, Non-Solid Tumors, Circulating Tumor Cells


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The global cancer incidence and the heterogeneity of tumors and tumor biomarkers pose a significant challenge to the human resource involved in this research area. Medical doctors and scientific researchers often gather in a common effort to develop innovative and efficient tools (drug compounds, diagnostic methods and devices) for the early detection and curing of cancer. The task becomes even harder when the investigated item (biomarker or the whole cell) is not located within a fixed spot, as is the case of non-solid tumors/non-adherent cancer cells (e.g. lymphoblasts, myeloblasts, circulating tumor cells). In this regard, nanotechnology-based approaches may come as an alternative to the complex, expensive and time-consuming current lab-methods used for the capture and identification of this specific type of cancer cells, allowing for a faster and less-laborious imaging and identification.

This Research Topic puts a spotlight on the nanotechnology-derived products (nanoparticles and nanostructured materials) that can be successfully used in combination with validated microspectroscopic techniques such as Raman, infrared (IR) or fluorescence spectroscopy, for the efficient and rapid detection of non-adherent cancer cells and associated biomarkers. The up-to- date research related to the implementation of such innovative strategies, by highlighting their strengths and limitations in comparison with validated clinical techniques, will be presented. Comprehensive overview of the origin, properties, testing and potential use of nanotechnology-related vs conventional liquid biopsy as a multimodal diagnostic and prognostic tool for the assessment of non-solid tumors is also open to discussion.

The aim of this Research Topic is to highlight promising, novel, recent and currently ongoing research on the development of nanoparticle and nanostructure-related spectroscopic tools for the real-time liquid biopsy and imaging of non-solid tumors/non-adherent cancer cells. Areas to be covered may include, but are not limited to:

• Multifunctional nanoparticles as sensitivity enhancers for cancer detection
• Nanostructured materials for non-adherent cancer cell capture and identification
• Real-time liquid biopsy in cancer: non-adherent cancer cell detection and analysis
• Micro/nano-fluidic devices for cancer biomarker detection and screening
• Nanotechnology approaches for in-flow detection of circulating tumor cells (CTCs)
• Microspectroscopic methods for the identification and classification of non-solid tumors
• Nanostructures and nanomaterials for detecting malignancy-derived nucleic acids or exosomes
• Perspectives on clinical application and translation of nano-integrated liquid biopsy techniques

Original research papers and up-to-date review articles are welcome.

Topic Editor Dr. Long-Sheng Lu has received industrial-academic collaboration grants from Cancerfree Biotech Inc., Bosomeer Biotech Inc., Unimed Inc. and Nanoray Biotech Co. Ltd. He holds 5 international patents with regards to cancer radiotherapy and precision cancer medicine. Dr. Dana Cialla-May holds 3 patents regarding method for identifying viruses, surface reinforcing plasmonic substrate and Activated 3-D nano surface, process for its production and its use. The other Topic Editors declare no competing interests regarding the Research Topic subject.


Keywords: Nanoparticles, Nanostructures, Liquid Biopsy, Spectroscopic Imaging, Microspectroscopy, Non-Solid Tumors, Circulating Tumor Cells


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

27 November 2020 Abstract
26 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

27 November 2020 Abstract
26 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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