About this Research Topic
Early detection is vital to reduce oral cancer-associated morbidity and mortality. More than 95% of oral cancers are squamous cell carcinomas which are preceded by precancerous or potentially malignant disorders. Among these, the most common is oral leukoplakia (OL), with a prevalence of 2-3% in total population. Although a correlation with tobacco and alcohol has been shown, the etiology is poorly understood as it can also occur in patients without risk factors. The malignant transformation rate, according to WHO, is between 1-2%, therefore, assessing the risk of malignant transformation is a great challenge. Multiple clinical, histological and molecular prognostic factors have been reported, without a definitive conclusion.
The aim of this Research Topic is to publish the most recent perspectives and findings about progression of oral potentially malignant disorders. We are interested in articles with important data about clinical or histological parameters, and molecular biomarkers that try to clarify how these disorders progress to cancer, and how this information can help to predict malignant transformation, with an impact on clinical treatment and monitoring decisions, as well as the development of therapeutic targets.
We welcome high-quality reviews and original research articles involving observational and experimental data of basic and clinical research. The scope includes different areas of interest, such as: Epidemiology, Clinics, Histopathology, Immunohistochemistry, Bioinformatics, Digital Pathology, Cell and Molecular Biology (including genomics, epigenomics, transcriptomics, proteomics and metabolomics).
The oral potentially malignant conditions that will be included in this topic are those considered in the last edition of the WHO Classification of Head and Neck Tumors, such as Erythroplakia, Erythroleukoplakia, Leukoplakia, Oral submucous fibrosis, Smokeless tobacco keratosis, Palatal lesions associated with reverse smoking, Lichen planus and Actinic keratosis.
Keywords: Oral leukoplakia, Dysplasia, Biomarkers, Malignant transformation, Precancerous conditions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.