About this Research Topic
Nanotechnology provides various novel methods, including (i) synthesis of the nanomaterials through the plant or microbial extracts, plasma, and physicochemical approach. (ii) development of nanoscale drug delivery system (nDDS) using the polymeric or other coating agents. (iii) conjugation of the receptor targeting molecules with nanomaterials to enhance therapeutic efficiency to cure various microbial and chronic infections. The synthesis approaches significantly impact the quality of these materials to battle against various diseases. Although these nanomaterials are effective in in-vitro systems, they are not promising in in-vivo systems due to less targeting ability and penetration towards the targeted pathological tissues. Therefore, the combination of the bioactive nanomaterials with nDDS can provide an efficient therapeutic effect over the individual activity.
Several researchers have reported the green synthesis of the metallic nanoparticles, such as silver, zinc, gold, Fe, etc., with challenging antibacterial and anticancer activity. However, these materials have shown promising activity in-vitro but not in in-vivo experiments. Moreover, the reproducibility of the green synthesized nanoparticles has had many questions due to the involvement of the various unknown bounded molecules from plants or microbes. Thus the elucidation of underlying mechanisms or identification of the molecules in synthesis of nanoparticles is essential. Moreover, utilization of the polymeric or other coating agents conjugated with ligand targeting the bacterial or cancer tissue receptors can improve targeting demand release, which leads to the more efficiency of therapeutics with minimal toxicity.
This Research Topic invites researchers to submit Original Research papers and Reviews/Mini-Reviews dealing with the advanced elucidation of mechanism and identification of molecules involved in green synthesis of nanoparticles, comparison of green, and physicochemical methods for fabricating nanomaterials for biomedical applications, and finally, how the targeted release of drug-using the nDDS conjugated with ligand improves the therapeutics. We encourage the submission of research on, but not restricted to, the following areas:
• Biochemical elucidation of green synthesis of nanoparticles
• Utilization and comprehensive approaches of green, chemical and physical approaches
• Plasma process for nanoparticles production for potential applications
• Stimuli-responsive nDDS
• Bio therapeutics of Metallic, bi-metallic, polymeric and nano-biocomposites
Keywords: Nanomaterials synthesis, green synthesis, Biochemical elucidation, Drug Delivery Systems, Biotherapeutics, sustainable nanomaterials, Disease management
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.