About this Research Topic
Bronchiolitis represents a clinical defined entity, imposing a significant morbidity burden in infants and children less than 2 years of age. Although there is a lack of a globally accepted definition, Bronchiolitis is most often described as a virus-induced inflammation of Bronchioles and surrounding tissues, characterized by variable difficulty in expiratory breathing; nevertheless, a highly heterogeneous variability regarding clinical presentation exits.
Currently, it is well accepted that within the context of Bronchiolitis, certain entities imposed significantly increased risk on subsequent occurrence of recurrent preschool wheeze and later asthma development. Recent data suggest that the underlying etiologic viral agent, mainly respiratory syncytial virus and rhinoviruses, have distinct genetics, pathogenetic mechanisms, clinical characteristics, and responses to treatments, thus affecting subsequent short- and long-term outcomes.
The aim of this research topic is to provide insight and to integrate current knowledge on interactions between bronchiolitis/preschool wheeze and risk of later asthma development. Submissions of Original Research, Methods, Perspective, Mini-Review, and Review articles are welcome. The subtopics of interest include, but are not limited to:
Etiologic viral Bronchiolitis' agents,
Clinical characteristics of Bronchiolitis and preschool wheeze, including symptoms and signs and disease severity,
Progression of lung function indices from preschool wheeze to later asthma
Treatment and subsequent asthma development
The impact of disease phenotypes
The role of differential immune responses immune responses to respiratory viruses detected during Bronchiolitis on asthma occurrence
Keywords: Bronchiolitis, wheeze, asthma, allergy, airways, pediatrics
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