Research Topic

Essential Oil-based Nanoformulations for Antimicrobial Activity

About this Research Topic

The emergence of multidrug-resistant pathogens is a great challenge to the medical and food technology fields and a major global health threat requiring novel therapeutic strategies. Among plant products, essential oils have significant antimicrobial properties that make them promising agents in the fight against human and food-borne pathogens. The synergistic interactions between essential oils, their bioactive compounds, their combination with other natural extracts, and known antibiotics are promising. In addition, the nanoformulation approaches to boost the antimicrobial activity of essential oils are reviewed in terms of bio-efficiency, stability, and design of the nanostructured delivery systems. Thus, essential oils in combination with nano-based strategies may cope with infections caused by drug-resistant pathogens and may offer possibilities for reducing antibiotic use. Nano-encapsulated antimicrobials can provide controlled release kinetics, while efficiently enhancing permeability, stability, and solubility.

Nowadays, approximately 700,000 people die each year due to drug-resistant infections, and it is estimated that multidrug-resistance in pathogens could cause 10 million deaths/year by 2050. Although uncertainties behind this estimation were reported, the resistance to antimicrobials is undoubtedly one of the greatest challenges modern medicine needs to face. The intensive and inappropriate use of antibiotics, self-drug abuse, shortfall of the antibiotic course, nosocomial infections, unsafe disposal of biomedical waste, and antibiotic use in food as well as in veterinary practices are the most common factors associated with antimicrobial resistance. Among the plant-derived products, essential oils (EOs) are one of the most diverse classes of specialized metabolites that play an important role in the plant's defensive response to various insults, including microbial attacks. Due to multi-component composition, EOs exhibit simultaneous activities towards different bacterial targets. Therefore, there is less probability that bacteria develop resistance towards EOs in comparison with traditional antibiotics. The nano-based formulation of EOs can provide stability to the EOs formulation, control release, as well as enhanced efficacy for antimicrobial activity.

We Invite Researchers to contribute Original Research, Reviews and Mini-reviews exploring, but not limited to, the following research areas:
• Development of EOs formulation for antimicrobial activity
• Synergistic activity of the combination of two or more essential oil or combination of essential oil with other natural extract or antibiotics or nanoparticles
• Development of nanoformulation of essential oils for antimicrobial activity
• Encapsulation of EOs for antimicrobial activity
• Essential oils based nanoformulation for food packaging application
• Essential oils based nanoformulation for biomedical application


Keywords: Essential Oil nanoformulation, Antimicrobial activity, nanoparticles, food packaging, biomedical applications


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The emergence of multidrug-resistant pathogens is a great challenge to the medical and food technology fields and a major global health threat requiring novel therapeutic strategies. Among plant products, essential oils have significant antimicrobial properties that make them promising agents in the fight against human and food-borne pathogens. The synergistic interactions between essential oils, their bioactive compounds, their combination with other natural extracts, and known antibiotics are promising. In addition, the nanoformulation approaches to boost the antimicrobial activity of essential oils are reviewed in terms of bio-efficiency, stability, and design of the nanostructured delivery systems. Thus, essential oils in combination with nano-based strategies may cope with infections caused by drug-resistant pathogens and may offer possibilities for reducing antibiotic use. Nano-encapsulated antimicrobials can provide controlled release kinetics, while efficiently enhancing permeability, stability, and solubility.

Nowadays, approximately 700,000 people die each year due to drug-resistant infections, and it is estimated that multidrug-resistance in pathogens could cause 10 million deaths/year by 2050. Although uncertainties behind this estimation were reported, the resistance to antimicrobials is undoubtedly one of the greatest challenges modern medicine needs to face. The intensive and inappropriate use of antibiotics, self-drug abuse, shortfall of the antibiotic course, nosocomial infections, unsafe disposal of biomedical waste, and antibiotic use in food as well as in veterinary practices are the most common factors associated with antimicrobial resistance. Among the plant-derived products, essential oils (EOs) are one of the most diverse classes of specialized metabolites that play an important role in the plant's defensive response to various insults, including microbial attacks. Due to multi-component composition, EOs exhibit simultaneous activities towards different bacterial targets. Therefore, there is less probability that bacteria develop resistance towards EOs in comparison with traditional antibiotics. The nano-based formulation of EOs can provide stability to the EOs formulation, control release, as well as enhanced efficacy for antimicrobial activity.

We Invite Researchers to contribute Original Research, Reviews and Mini-reviews exploring, but not limited to, the following research areas:
• Development of EOs formulation for antimicrobial activity
• Synergistic activity of the combination of two or more essential oil or combination of essential oil with other natural extract or antibiotics or nanoparticles
• Development of nanoformulation of essential oils for antimicrobial activity
• Encapsulation of EOs for antimicrobial activity
• Essential oils based nanoformulation for food packaging application
• Essential oils based nanoformulation for biomedical application


Keywords: Essential Oil nanoformulation, Antimicrobial activity, nanoparticles, food packaging, biomedical applications


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 November 2020 Abstract
12 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 November 2020 Abstract
12 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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