Research Topic

Host immune responses against Staphylococcus aureus infections and mechanisms of protection: closing the knowledge gap to develop efficacious vaccines

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Current antibiotics are not efficacious against emerging multidrug resistant Staphylococcus aureus strains. Therefore, there is an urgent need to develop vaccines to target this pathogen. However, both active and passive immunization strategies have thus far failed to show efficacy in humans. By limiting the ...

Current antibiotics are not efficacious against emerging multidrug resistant Staphylococcus aureus strains. Therefore, there is an urgent need to develop vaccines to target this pathogen. However, both active and passive immunization strategies have thus far failed to show efficacy in humans. By limiting the ability to interpret both preclinical and clinical data the lack of known correlates of protection in humans represents one of the major factors behind these disappointing results.
The aim of this research topic is to provide novel data, opinions and literature reviews on mechanisms of protection potentially important against S. aureus infection. To that end, authors can choose to submit original research papers or opinion and review articles on preclinical and clinical observations that can shed new light on immune responses to the pathogen or to its antigens following vaccination. Regarding this latter point, the role played by different antigens and adjuvants in stimulating and driving the immune response will also be discussed. Furthermore, animal models and in vitro assays that can be exploited to study mechanisms of protection will also be of interest to this forum.
We believe that this is a unique chance to build a unified view provided by microbiologists, immunologists and vaccine researchers on a fundamental question, which has long been awaiting an answer.


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