About this Research Topic
Fungi are the principal decomposers for diverse ecosystems, having evolved a wide range of biosynthetic capabilities to thrive on organic-rich substrates. These capabilities are of increasing interest to industry as they enable fungal species to use abundant but recalcitrant renewable substrates, synthesize many bioactive, medicinal, and/or energy-rich compounds, degrade toxic compounds, and grow in hostile environments.
Recent advances in systems and synthetic biology now enable the rapid characterization and development of fungal species to leverage these capabilities for industrial biotechnology. Multi -omics analysis and functional genomics powered by CRISPR technologies allow the in-depth mining of complex metabolic network to discover novel biosynthetic routes for needed chemicals. Sequence resources, emerging epigenetic and chromosomal capture technologies, and CRISPR-based approaches provide a wealth of tools to facilitate the precise and rapid optimization of strains for industrial applications such as enzyme production and chemical synthesis. And finally, paradigms from synthetic biology and metabolic engineering such as dynamic gene regulation, compartmentalization, and much more are now being deployed to produce compounds in fungal hosts at high yield.
This Research Topic invites manuscripts that focus on the application of systems and synthetic biology approaches, including established and novel biomolecular and computational strategies, to advance the development of emerging fungal platforms. We particularly welcome manuscripts that detail:
• The development of genetic tools and/or CRISPR-based approaches for fungal species
• Mining of fungal genomes for superior biocatalysts
• Metabolic engineering of fungal hosts
• Optimization of fungal protein expression via genetic approaches
• Elucidation of fungal biosynthetic pathways
• Systems-biology studies to characterize the genetic potential of fungal platforms
• Development of biosynthetic consortia that include fungal members
• Genetic development of fungal hosts for industrial applications (e.g. chemical synthesis, biosensors, environmental remediation, etc)
Keywords: synthetic biology, systems biology, metabolic engineering, protein expression, microbial communities
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.