About this Research Topic
Glycocalyx covers the surface of multiple cells. It is closely associated with various physiological and pathophysiological events, including cytoskeleton remodeling, vascular leakage, edema, angiogenesis, and tumor growth and metastasis. Some components of glycocalyx are promising biomarkers for many vascular and vascular-related diseases, which are applied for sepsis, shock, coronary artery disease, COVID-19, hypertension, diabetes, ischemia-reperfusion injury, and pre-eclampsia. There are also the critical elements involved in cell-cell and cell-external environment crosstalks in these diseases. The structure of glycocalyx could be modified by bioactive serum factors, drugs, mechanical forces, etc. As an essential signaling mediator, glycocalyx governs the transduction of the extracellular signals into cellular responses. It is involved in proliferation, apoptosis, migration, adhesion, autophagy, oxidative stress, angiogenesis, and metastasis. It is of great significance to investigate whether glycocalyx mediates the interaction among cells, with which components are associated with the external environment, and how.
The mechanisms underlying the vascular and vascular-related diseases are likely to be multifactorial. The glycocalyx associated with the microenvironment decides the fate of cells and regulates coagulation, permeability, migration, adhesion, and inflammation. Up to date, the research in glycocalyx focuses on determining the mechanisms by which the structure and composition of the glycocalyx modified, with particular emphasis on synthesis and regeneration in the face of pathological changes in structure and function. However, it is still unclear how specific
components of glycocalyx such as GAG and PGs can be targeted to unravel phenotypic and functional outcomes. Increasing upstream and downstream signal molecules of glycocalyx have been identified, but how they interact with each other and in which signaling cascade in the diseases is yet to be elucidated. The topic will focus on the signaling associated with glycocalyx on aspects of mechanisms, actions, effector molecules, signaling molecule interactions, and interconnection networks.
Understanding of glycocalyx associated signaling is crucial for developing new strategies for vascular and vascular-related disease therapy. Therefore, this research topic invites contributions on glycocalyx associated signaling, including but not limited to:
• The signals and molecular pathways related to glycocalyx
• Glycocalyx and its associated signaling in vascular diseases
• Glycocalyx and its associated signaling in vascular-related diseases
• Glycocalyx and its associated signaling in physiology
• Signaling involved in the protection of glycocalyx
• Signaling engaged in the modification of glycocalyx
• Detection tool of the glycocalyx and its associated signaling
• Glycocalyx and its associated signaling in angiogenesis
We welcome especially Original Research Articles, Short Communication, and Mini-reviews.
Keywords: Glycocalyx, homeostasis, dysfunction, cell response, molecular mechanism
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