About this Research Topic
Over the past decade, G protein-coupled receptor deorphanization programmes have revealed an unlikely source of endogenous ligands - metabolic intermediates. Various metabolic intermediate/receptor pairs have since been implicated in several physiological and pathological processes, such as diabetes, lipid handling and hypertension. In this Research Topic, the challenges of drug discovery at these often low potency and poorly defined receptors is explored with emphasis on Free Fatty Acid receptors 1, 2 and 3, GPR120, TGR5, GPR81, GPR35, SUCNR1 and GPR109A and GPR109B.
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