Research Topic

Emerging Intestinal Protozoa: Molecular epidemiology, Infection or Co-infection, Immunity, and Evolution

About this Research Topic

Emerging intestinal protozoa, such as Cryptosporidium, Giardia, Cyclospora, and microsporidia, have become a major threat to both immunocompetent and immunocompromised individuals worldwide and have had a major impact on the global economy. These protozoa are prevalent in food and water supplies, not only in the tropics, but also in temperate climates, and they invade the body by disrupting the intestinal epithelium and mainly causing persistent diarrhea.
The past two decades have seen major advances in research on these increasingly important pathogens. However, while much has been learned in recent years about the epidemiology of infections due to the rapid development of molecular tools, the pathogenesis of infections are still unclear and treatment remains a tremendous challenge. Additionally, novel approaches to improving the treatment of food and water are still lacking.
In this Research Topic, we aim to provide a comprehensive up-to-date account on the status of relevant research in the field, in order to aid the resolution of the problem of emerging intestinal protozoa mentioned earlier. The main aims are (1) to highlight new tools and approaches in molecular characterization/diagnosis/typing of these pathogens, (2) to elucidate their biology and epidemiology, (3) to determine the co-infection status in several susceptible populations such as AIDS and cancer patients, and (4) to present the new progress in drug discovery and treatment against these pathogens, as well as the mechanisms underlying the host–pathogen interactions.
This Research Topic welcomes contributions in the form of Original Research, Review and Mini-Review that focus on, but are not limited to, the following issues:
• Molecular taxonomy, detection/diagnosis/typing, and molecular epidemiology of the five pathogens mentioned earlier
• Evaluation of existing diagnostic tools and development of novel detection tools
• Co-infections in susceptible populations such as immunocompromised individuals
• Host-pathogen interactions, pathogenicity, evolution and immunology
• New findings related to drug discovery and treatment


Keywords: Emerging Intestinal Protozoa, co-infection, immunity, pathogenesis, epidemiology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Emerging intestinal protozoa, such as Cryptosporidium, Giardia, Cyclospora, and microsporidia, have become a major threat to both immunocompetent and immunocompromised individuals worldwide and have had a major impact on the global economy. These protozoa are prevalent in food and water supplies, not only in the tropics, but also in temperate climates, and they invade the body by disrupting the intestinal epithelium and mainly causing persistent diarrhea.
The past two decades have seen major advances in research on these increasingly important pathogens. However, while much has been learned in recent years about the epidemiology of infections due to the rapid development of molecular tools, the pathogenesis of infections are still unclear and treatment remains a tremendous challenge. Additionally, novel approaches to improving the treatment of food and water are still lacking.
In this Research Topic, we aim to provide a comprehensive up-to-date account on the status of relevant research in the field, in order to aid the resolution of the problem of emerging intestinal protozoa mentioned earlier. The main aims are (1) to highlight new tools and approaches in molecular characterization/diagnosis/typing of these pathogens, (2) to elucidate their biology and epidemiology, (3) to determine the co-infection status in several susceptible populations such as AIDS and cancer patients, and (4) to present the new progress in drug discovery and treatment against these pathogens, as well as the mechanisms underlying the host–pathogen interactions.
This Research Topic welcomes contributions in the form of Original Research, Review and Mini-Review that focus on, but are not limited to, the following issues:
• Molecular taxonomy, detection/diagnosis/typing, and molecular epidemiology of the five pathogens mentioned earlier
• Evaluation of existing diagnostic tools and development of novel detection tools
• Co-infections in susceptible populations such as immunocompromised individuals
• Host-pathogen interactions, pathogenicity, evolution and immunology
• New findings related to drug discovery and treatment


Keywords: Emerging Intestinal Protozoa, co-infection, immunity, pathogenesis, epidemiology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

07 November 2020 Abstract
07 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

07 November 2020 Abstract
07 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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