Research Topic

Blood Contacting Medical Devices in Application of Cardiovascular System

About this Research Topic

Blood contacting medical devices (BCMDs), such as ventricular assist device (VAD), extracorporeal membrane oxygenation (ECMO), artificial heart valve, vascular graft, and stent et al. were invented to save the lives of patients with cardiovascular and respiratory diseases. Although these devices have made a great achievement, the benefits of utilizing these are not without risks. For example, clinical complications, such as thrombosis, bleeding, infection, and restenosis, are often seen in the clinical applications of BCMDs, hampering patients' recovery. Lots of research has been carried out to understand how BCMDs affect the blood components and blood vascular systems, contributing to these complications. Better understanding of the mechanisms behind the BCMD-associated clinical complications can help to guide the development of more biocompatible BCMDs, decrease the risk of device-associated complications, and assist physicians in tailored patient management.

The goal of this Research Topic is to solicit recent advances of blood contacting medical devices (BCMDs), including the new applications of BCMDs, new technology for developing BCMDs, new BCMDs, studies of BCMD-related clinical complications, and analysis of BCMDs (i.e. in-vitro, in-vivo, computational etc.). Researchers are encouraged to submit original work related to engineering progress and development, clinical results, and scientific research findings. Relevant results from the development in BCMDs, computational analysis and theoretical and numerical models, and BCMDs-induced morphological and functional alternation of cells, tissues, and systems in in-vitro, in-vivo and clinical studies are highly favored.

Potential topics include but are not limited to:
• New technology of blood contacting medical devices (BCMDs) in cardiovascular and respiratory;
• Computational analysis in developing and optimizing BCMDs;
• Theatrical and numerical models for evaluating BCMD-associated damages (i.e. cells, tissues, etc.), estimating clinical complications, patients' medication, among others;
• Structural/Functional alternation of blood cells and blood vessels induced by BCMDs;
• Signaling pathway of device-induced blood damage (cells and proteins) in BCMDs' patients;
• The mechanism of clinical complications in patients implanted with BCMDs;
• The combination effects of device-induced hemostasis dysfunction and anticoagulation drugs;


Keywords: Biomedical engineering, hemodynamics, implantable biomedical device, circulatory assist device, Computational Fluid Dynamics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Blood contacting medical devices (BCMDs), such as ventricular assist device (VAD), extracorporeal membrane oxygenation (ECMO), artificial heart valve, vascular graft, and stent et al. were invented to save the lives of patients with cardiovascular and respiratory diseases. Although these devices have made a great achievement, the benefits of utilizing these are not without risks. For example, clinical complications, such as thrombosis, bleeding, infection, and restenosis, are often seen in the clinical applications of BCMDs, hampering patients' recovery. Lots of research has been carried out to understand how BCMDs affect the blood components and blood vascular systems, contributing to these complications. Better understanding of the mechanisms behind the BCMD-associated clinical complications can help to guide the development of more biocompatible BCMDs, decrease the risk of device-associated complications, and assist physicians in tailored patient management.

The goal of this Research Topic is to solicit recent advances of blood contacting medical devices (BCMDs), including the new applications of BCMDs, new technology for developing BCMDs, new BCMDs, studies of BCMD-related clinical complications, and analysis of BCMDs (i.e. in-vitro, in-vivo, computational etc.). Researchers are encouraged to submit original work related to engineering progress and development, clinical results, and scientific research findings. Relevant results from the development in BCMDs, computational analysis and theoretical and numerical models, and BCMDs-induced morphological and functional alternation of cells, tissues, and systems in in-vitro, in-vivo and clinical studies are highly favored.

Potential topics include but are not limited to:
• New technology of blood contacting medical devices (BCMDs) in cardiovascular and respiratory;
• Computational analysis in developing and optimizing BCMDs;
• Theatrical and numerical models for evaluating BCMD-associated damages (i.e. cells, tissues, etc.), estimating clinical complications, patients' medication, among others;
• Structural/Functional alternation of blood cells and blood vessels induced by BCMDs;
• Signaling pathway of device-induced blood damage (cells and proteins) in BCMDs' patients;
• The mechanism of clinical complications in patients implanted with BCMDs;
• The combination effects of device-induced hemostasis dysfunction and anticoagulation drugs;


Keywords: Biomedical engineering, hemodynamics, implantable biomedical device, circulatory assist device, Computational Fluid Dynamics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

09 May 2021 Manuscript
08 June 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

09 May 2021 Manuscript
08 June 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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