About this Research Topic
Nuclear receptors (NRs) are a family of ligand-activated transcription factors involved in all aspects of biological processes, from embryonic development to adult homeostasis. NRs regulate gene expression through direct binding to the consensus DNA element in the promoter region of the target genes or through protein-protein interaction with other NRs, transcriptional factors, or co-factors (co-activators and co-repressors). NRs also function via non-genomic actions, such as through modulation of kinase activities and intracellular calcium levels. However, emerging evidence suggests that NRs may mediate inter-tissue interactions and regulate noncoding RNAs (microRNAs and long-noncoding RNAs).
We welcome original research articles, reviews, mini reviews, or perspectives that address any aspect of biological functions and activities regulated by NRs.
Potential topics include but are not limited to:
• Direct interaction between NRs resulting in functional regulation of the partner
• Regulation of nuclear cofactors by NR and its relevance for NR function
• Nuclear cofactor binding competition between NRs and its function in normal or pathological conditions.
• Regulation of transactivation either through alternate regulatory mechanism such as phosphorylation/methylation or through the production of endogenous ligands.
• Analysis of nuclear receptor and/ or cofactor expression in disease models providing mechanistic insights into the crosstalk between NRs and inter-tissue interactions
• Genomics, proteomics, and metabolomics analysis of transcriptional networks, discovery of novel genes and biological processes regulated by NRs.
• Pharmacological activation of NRs in normal or pathological conditions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.