About this Research Topic
Cryptosporidium is an important emerging zoonotic pathogen that causes diarrhea in vertebrate hosts worldwide. Forty-one valid species and approximately sixty genotypes of Cryptosporidium have been identified or described in animals and humans. Results from the Global Enteric Multicenter Study (GEMS) showed that Cryptosporidium is among the leading causes of moderate to severe diarrhea in children under 2 years. Owing to the significant disease burden in developing countries, the World Health Organization has included Cryptosporidium in the “Neglected disease initiative” since 2004. There are no fully efficacious treatment options or vaccines for cryptosporidiosis. Although nitazoxanide is approved for the treatment of cryptosporidiosis in immunocompetent individuals, it has not been approved for use by immunocompromised patients. The mechanisms that contribute to disease caused by Cryptosporidium are not totally understood, but are clearly multifactorial and involve both parasite and host factors.
Goal (approx. 100 – 200 words)
The pathogenic mechanisms of Cryptosporidium have been rarely studied, which is one of the major obstacles to explore anti-cryptosporidiosis drugs or vaccines. The aim of this Research Topic is to gather the most updated studies on pathogenic mechanisms of Cryptosporidium. We hope that this Research Topic will help to better understand the advances of pathogenic mechanisms of Cryptosporidium and provide more inspiration for the control and prevention strategies.
Scope and information for Authors (approx. 100-150 words)
For this Research Topic, we welcome Original Research and Review articles focusing particularly on the following themes:
• Cryptosporidium invasion mechanisms
• Cryptosporidium gene/protein functions
• Cryptosporidium and gut microbiota interactions
• Cryptosporidium coinfection with other enteropathogens
• Mucosal immune responses to Cryptosporidium infection
• Cryptosporidium immune modulation.
Keywords: Cryptosporidium, cryptosporidiosis, pathogenic mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.