Research Topic

Multifunctional Nanomaterials for Tissue Regeneration: Mechanisms of Interaction with Cells and Toxicology

About this Research Topic

Tissue Engineering is attracting worldwide interest, demonstrating the immeasurable possibilities to successfully overcome the lack of organ donors. Nevertheless, to date most strategies so far lack crucial features for appropriately mimicking native live tissues, guiding the surrounding microenvironment to ...

Tissue Engineering is attracting worldwide interest, demonstrating the immeasurable possibilities to successfully overcome the lack of organ donors. Nevertheless, to date most strategies so far lack crucial features for appropriately mimicking native live tissues, guiding the surrounding microenvironment to promote self-healing and towards the development of tailored functionally-graded tissues with reduced toxicity. Tailoring cell-construct interactions and implementing appropriate and finely tuned chemical/molecular signals, contribute to achieve the structural and functional mimicry of the physiological process of tissue formation. Nano-scale features of developed tissues and medical implants may drive dynamic modeling in response to environmental stimuli.

Current improvements in understanding the interactions between implants and human cells have led to the rapid development of novel artificial tissues and bioconductive medical devices. However, the design of a surface that guides its surrounding biology is still a crucial issue in tissue engineering research. New multifunctional nanomaterials can potentially allow the design of tailored implants thanks to their nanoscale features capable of driving cell behavior. These can be also combined with engineered proteins and extracellular vesicles from biological fluids to enhance implant bioconductivity and modulate cell interaction. The goal of this Research Topic is to highlight the potential of nanomaterials design and formulation in driving unique cell response and to highlights possible toxicology mechanisms after in vivo implantation.

To this aim, we will collect research papers and reviews of recent literature focused on new nanomaterials and/or synthesis methods employed for artificial tissues as well as for medical device production. How can the latest development of nanotechnology improve cell interaction with implants’ surface? How soon technologies like bioprinting can be transferable to the clinical setting? How much can we control the long-term toxicity of these new materials inside the body? Can we reduce the immune response by modifying the material through clever design? Can biotechnology and the use of cellular extracts improve outcome in vivo and reduce immunotoxicity? These are some of the questions that will be tackled in this Research Topic.


Original papers or up-to-date reviews/perspective investigating/focusing on related topics are welcome, including:
• direct and indirect interactions of nanomaterials with cells and their effect on cellular viability and behavior
• new generation of nanomaterials (synthetic nano stem cells/magnetic mesoporous nanoparticles/thermal reversible nanogels etc.) and noval synthetic approaches
• ways to improve biomimicry and overcome toxic properties of nanomaterials, nanocarriers and engineered proteins during production and/or through functionalization, including bioprinting and 3D printing technologies, among others
• effects of cell-nanomaterial interactions on the release and content of extracellular vesicles
• novel strategies for scaffold design for specialized cellular functions, addressing specific tissues and body compartments
• toxicology studies on nanomaterials and biodegradation of scaffolds


Keywords: Nanomaterials, Engineered Tissues, 3D Printing and Bioprinting, Therapeutic Strategies, Nanotechnology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

27 March 2021 Manuscript
26 April 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

27 March 2021 Manuscript
26 April 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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