About this Research Topic
Stroke is the second leading cause of death in the world, and has become the leading cause of death in some countries, such as China. It has imposed a huge economic and social burden all over the world. Moreover, ischemic stroke caused by intracranial artery stenosis or acute occlusion is one of the main causes of stroke. Considering the severity of the symptomatology, adequate ways to manage these conditions are still lacking. The few available treatments, such as medical therapy and endovascular therapy, still lack sufficient efficacy evidence. One of the reasons may be that our understanding of the disease is not enough. Therefore, we urgently need to provide more adequate treatment based on more accurate evaluation of the disease.
This Research Topic focuses on the precise diagnosis and treatment of intracranial artery stenosis or acute occlusion. We aim to include the most recent advances in this area. The cause and manifestation of the disease can be investigated from multiple dimensions, such as molecular biology, pathology, anatomy and hemodynamics. New evaluation methods, such as big data and artificial intelligence, have been developed recently. In addition to routine patients, we will pay great attention to research addressing non-routine people such as the elderly, minorities, atypical manifestations, and those with special comorbidities, as well as to research addressing the early prevention of intracranial atherosclerotic disease and rehabilitation of stroke.
Welcomed contributions to this Research Topic include, but are not limited to:
• Mechanical pathways relevant to intracranial artery stenosis or acute occlusion (from molecular, pathological, anatomic, metabolic perspective).
• Technical considerations regarding currently available interventions such as endovascular therapy.
• Methods to better evaluate the severity of the disease or prognosis, in order to conduct better patient selection.
• Strategies for medical treatment or endovascular therapy for intracranial artery stenosis or acute occlusion.
• Strategies for disease prevention and rehabilitation interventions.
We would like to acknowledge that Dr. Tao Wang, Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, has acted as a coordinator and has contributed to the preparation of the proposal for this Research Topic.
Keywords: intracranial artery stenosis, intracranial artery occlusion, ischemic stroke, thrombectomy, endovascular therapy, diagnosis and treatment, precise medicine
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