Research Topic

Green Nanoparticles and their Application in Inflammation via Targeting Cellular Signaling

About this Research Topic

Green-synthesized nanoparticles have shown to possess numerous bio-functionalities associated with anti-inflammatory potential. Nanotechnology is providing new horizons to medical diagnostics and therapeutics through early diagnosis and treatment of inflammation-related disorders.

Cell signaling is involved in basic pathophysiological actions at molecular levels in cells. A variety of signaling molecules like proteins, enzymes, etc. are associated with the regulation of the homeostatic functioning of cells. Any aberrations in signaling pathways might cause cellular dysfunction, ultimately leading towards the development of the disease. For instance, kinases, various signaling cascades, and other molecular substances are linked to inflammation. Inflammation associated ailments include a vast range of diseases and conditions such as autoimmune diseases, allergy, asthma, hepatitis, coeliac disease, glomerulonephritis, inflammatory bowel disease, cancer, pre-perfusion injury, and transplant rejection. Controlling the aberrant signaling cascades is one of the foremost choices for the development of drugs to treat various inflammation-associated diseases and conditions.

Green nanomaterials could constitute one of the best sources for drug development. Nano-formulations influence the pharmaco-dynamics and pharmaco-kinetics of the drug and direct the drug release at the target site. Green synthesized nanoparticles will replace toxic chemicals with natural substances like phytochemicals as reducing agents, thus offering an effective alternative to chemical and physical means of nanoparticle synthesis. Currently, several investigations are being conducted on cell signaling pathways with the objective to develop target-specific drugs for treating inflammation-associated diseases. The present topic will focus on understanding the various anti-inflammatory mechanisms adopted by nanoparticles.

This Research Topic welcomes Original Research and Review articles in the field of green synthesis of nanoparticles and nanomaterials with applications focusing on (but not limited to):

• Targeting specific signaling proteins
• Targeting different signaling pathways involved in inflammation.
• Molecular mechanism by which nanoparticles exhibit their anti-inflammatory action
• The potential application of nanoparticles as a drug delivery vehicle
• Microbial, algal, and plant-mediated nanoparticles and assessment of their anti-inflammatory effects and related mechanisms


Keywords: Nanoparticles, Inflammation, Cancer, Phytochemicals, Molecular Mechanism, Cellular Signalling


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Green-synthesized nanoparticles have shown to possess numerous bio-functionalities associated with anti-inflammatory potential. Nanotechnology is providing new horizons to medical diagnostics and therapeutics through early diagnosis and treatment of inflammation-related disorders.

Cell signaling is involved in basic pathophysiological actions at molecular levels in cells. A variety of signaling molecules like proteins, enzymes, etc. are associated with the regulation of the homeostatic functioning of cells. Any aberrations in signaling pathways might cause cellular dysfunction, ultimately leading towards the development of the disease. For instance, kinases, various signaling cascades, and other molecular substances are linked to inflammation. Inflammation associated ailments include a vast range of diseases and conditions such as autoimmune diseases, allergy, asthma, hepatitis, coeliac disease, glomerulonephritis, inflammatory bowel disease, cancer, pre-perfusion injury, and transplant rejection. Controlling the aberrant signaling cascades is one of the foremost choices for the development of drugs to treat various inflammation-associated diseases and conditions.

Green nanomaterials could constitute one of the best sources for drug development. Nano-formulations influence the pharmaco-dynamics and pharmaco-kinetics of the drug and direct the drug release at the target site. Green synthesized nanoparticles will replace toxic chemicals with natural substances like phytochemicals as reducing agents, thus offering an effective alternative to chemical and physical means of nanoparticle synthesis. Currently, several investigations are being conducted on cell signaling pathways with the objective to develop target-specific drugs for treating inflammation-associated diseases. The present topic will focus on understanding the various anti-inflammatory mechanisms adopted by nanoparticles.

This Research Topic welcomes Original Research and Review articles in the field of green synthesis of nanoparticles and nanomaterials with applications focusing on (but not limited to):

• Targeting specific signaling proteins
• Targeting different signaling pathways involved in inflammation.
• Molecular mechanism by which nanoparticles exhibit their anti-inflammatory action
• The potential application of nanoparticles as a drug delivery vehicle
• Microbial, algal, and plant-mediated nanoparticles and assessment of their anti-inflammatory effects and related mechanisms


Keywords: Nanoparticles, Inflammation, Cancer, Phytochemicals, Molecular Mechanism, Cellular Signalling


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

22 February 2021 Abstract
28 June 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

22 February 2021 Abstract
28 June 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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