Research Topic

Biocatalytic Cascade Reactions

About this Research Topic

Today's chemicals are rarely the result of one single transformation but rather the consequence of several individual steps. Classically, these individual steps are performed sequentially including isolation and purification of the intermediate products. This approach is rather time- and resource-consuming, binds production infrastructure and generates considerable amounts of wastes. Therefore, it is not astonishing that so-called cascade reactions are gaining considerable interest from academic and industrial research.

The aim of this special issue is to showcase the current state-of-the-art, the potential, but also the current limitations of cascade reactions. Contributions reporting reactions involving sequences of biocatalysts (enzymes or whole cells) or combinations of biocatalysts with chemical catalysts (including, but not limited to metal-, organo-, electro-, photo-catalysis) are welcome for this special issue. The process engineering of cascade reactions that have demonstrated the potential for large scale, even industrial synthesis are also highly appreciated.


Keywords: Cascade Reactions, Biocatalysis, Process Engineering, Chemical synthesis, Biotransformation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Today's chemicals are rarely the result of one single transformation but rather the consequence of several individual steps. Classically, these individual steps are performed sequentially including isolation and purification of the intermediate products. This approach is rather time- and resource-consuming, binds production infrastructure and generates considerable amounts of wastes. Therefore, it is not astonishing that so-called cascade reactions are gaining considerable interest from academic and industrial research.

The aim of this special issue is to showcase the current state-of-the-art, the potential, but also the current limitations of cascade reactions. Contributions reporting reactions involving sequences of biocatalysts (enzymes or whole cells) or combinations of biocatalysts with chemical catalysts (including, but not limited to metal-, organo-, electro-, photo-catalysis) are welcome for this special issue. The process engineering of cascade reactions that have demonstrated the potential for large scale, even industrial synthesis are also highly appreciated.


Keywords: Cascade Reactions, Biocatalysis, Process Engineering, Chemical synthesis, Biotransformation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

12 December 2020 Abstract
11 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

12 December 2020 Abstract
11 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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