About this Research Topic
Current research suggests that there is an urgent need to discover novel effective biomarkers and therapeutic targets for the management of brain tumors. In this context, several studies have identified tumor-specific genetic and epigenetic alterations associated with the development of different tumors with a potential diagnostic or therapeutic application. Although the genetic background associated with brain tumors has been recognized, the precise epigenetic landscape behind the onset of brain tumors has not been identified yet.
Preliminary promising results showed that cancer-associated epigenetic modifications, including DNA methylation and the alteration of the expression levels of non-coding RNAs (ncRNAs), may be used as early diagnostic biomarkers for different tumors. In addition, pilot studies using specific methylating and demethylating agents or ncRNA mimics demonstrated the anti-proliferative effects of such epigenetic treatments in several in vitro tumor models.
On these bases, this Research Topic aims to collect up-to-date knowledge on epigenetic factors that could be used as diagnostic and prognostic biomarkers in neuro-oncology as well as novel therapeutic targets for the effective management of brain tumors.
We welcome Original Research, Case Reports, Systematic Review and Review articles. Potential topics will include, but are not limited to:
1. Epigenetic modulation induced by environmental and occupational neurotoxic risk factors;
2. Epigenetics modifications and brain tumors development and progression;
3. Novel biomarkers for the early diagnosis of glioma and glioblastoma;
4. Non-coding RNAs (miRNA, circRNA, lncRNA) for the diagnosis and treatment of glioma;
5. Epigenetic mechanisms and strategies to overcome drug resistance in brain tumors;
6. DNA methylation hotspots as an early marker of brain tumors development;
7. Novel epigenetic therapeutic strategies for brain tumors;
8. Tumors and neurological disorders.
The Topic Editors would like to recognize the contributions of Luca Falzone who has helped to organize and facilitate this project.
Keywords: Brain tumors, Epigenetics, Biomarkers, Therapeutic Targets, Glioma
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.