About this Research Topic
Infections of orthopedic implants post-surgery are considered as one of the most devastating complications to treat in modern trauma and orthopedic settings. The current treatment options which include extensive debridement, long term antibiotic therapy as well as revision surgeries are associated with considerable drug toxicity, side effects, bone loss and potential risk of re-infection and treatment failure. The treatment is complicated due to the biofilm nature of these infections which exhibit high recalcitrance to commonly deployed antibiotics. Despite aggressive treatment, such infections show poor clinical outcomes. As consequences, a huge socioeconomic burden, prolonged periods of hospitalization, life-long functional impairment for the patient along with high rates of morbidity and mortality are to be expected. Also, with rising drug resistance within the orthopedic settings, there is an essential need to explore and focus on new intervention strategies for improved management and treatment of orthopedic device-related infections (ODRIs).
As we face the harsh reality of increasing antimicrobial resistance (AMR) with concomitant decreasing pipeline of new antibiotics to fight it, it becomes mandatory to focus and work on novel therapeutic strategies and treatment options that can be used along with the conventional treatment algorithm for higher clinical success of orthopedic implant infections.
The present Research Topic will highlight the latest advances in the treatment approaches that can be taken to overcome and outsmart these bacteria in fighting implant infections in orthopedic settings. This Research Topic will bring a reservoir of data-based evidences related to novel therapeutics that work by either preventing the formation of resistant biofilm on the implants or by adopting biofilm disruption technology, with special focus on their effect on resistant pathogens such as methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant coagulase negative Staphylococci (MR-CoNS), vancomycin resistant S.aureus (VRSA) and vancomycin resistant Enterococci (VRE). Further, this Research Topic will focus on the recent advances in local drug delivery strategies, advanced biomaterial modulation, polymeric carriers for sustained release to prevent adhesion at the implant site. This will give a comprehensive insight into the latest developments that are the forefront of medical research.
The manuscripts (Review Articles, Research Articles) submitted in this Research Topic should fall into the following sub-themes.
1. Novel intervention strategies to either prevent or treat orthopedic implant/device related infections including the use of antimicrobial peptides, monoclonal antibodies and enzymes and other agents for the prevention of biofilm formation and their combined use.
2. New advances in local and targeted delivery of anti-infective agents for the management of ODRI in light of antimicrobial resistance, including improved drug delivery systems with different carriers and 3D printing of prosthetic materials impregnated with antimicrobials.
3. Recent advances in biomaterial technology to prevent bacterial adhesion at initial stage such as tethered antibiotics, encapsulated hydrogels or other innovative approaches.
The manuscripts should clearly include the novel/new therapeutic treatment strategy or advanced local delivery method or advanced biomaterial technology adopted, its mechanism of action, how it is better or superior to the already available and used protocols, its proven efficacy against drug resistant strains through various in vitro/ex-vivo/in vivo supporting data, its future implications and challenges associated and solutions suggested.
Keywords: orthopedic device-related infections (ODRIs), antimicrobial resistance (AMR), biofilms, novel therapeutics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.