About this Research Topic
The exponential growth of nanotechnology occurs due to its multiple applications in development of materials, engineering technology, drug delivery, molecular imaging, tissue engineering and biosensors. The size, composition, shape, as well as magnetic, optical and mechanical properties can have important consequences on biological behavior.
Environmental, occupational or medical exposure of organisms to nanoparticles generate reactive oxygen species (ROS), that at high levels activate programmed death signaling pathways, whereas at low levels, survival signaling mechanisms are stimulated. Also, nanoparticles-induced ROS influence selectively transcription factors, such as: Nrf2, MAPK/AP-1, NF-kB and HIF1A, and produce base modifications, abasic sites and strand breaks in nuclear and mitochondrial DNA, generating a risk to disrupt genome function with consequences on genome instability and mutation. Also, they can affect gene expression by altering the functions of histones and DNA modifying enzymes.
The aim of this Research Topic is to cover recent, promising and novel research trends regarding the impact of nanoparticles on genetic material of cells. Areas to be covered in this Research Topic may include, but are not limited to:
• organ or system genotoxicity and toxicogenomics related to nanoparticles' exposure
• in silico, in vitro and in vivo strategies to assess cytotoxic and genotoxic effects of natural and engineered nanoparticles
• correlation between materials physicochemical properties of nanoparticles and their genotoxicity
• conventional and innovative experimental models in genotoxicology
We welcome the following article types: Original Research, Brief Research Report, Methods, Perspective, Review, Mini Review, and Systematic Review.
Keywords: nanoparticles, genotoxicity, DNA, mutations, epigenetics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.