Research Topic

Signaling, Synthesis, and Secretion of Secondary Metabolites in Filamentous Fungi

About this Research Topic

Filamentous fungi impressively produce a large inventory of small bioactive molecules known as secondary metabolites. Secondary metabolites are often only made under certain environmental conditions and in response to particular stimuli, both biotic and abiotic. These environmental cues are recognized and transmitted within fungal cells resulting in the conditional expression of the genes and proteins involved in the biosynthesis of secondary metabolites. These biosynthetic pathways and the metabolites themselves can be confined to particular organelles within the cell allowing both for efficient biosynthesis and facilitated secretion of these small molecules.

This Research Topic will highlight current research on signal recognition, signal transduction, and regulation of metabolite expression. Also to be considered will be cellular compartmentalization of secondary metabolic pathways and secretion mechanisms by which metabolites are transported outside the cell.

We particularly welcome manuscripts that address:
• Signaling factors and signal recognition triggering secondary metabolite synthesis.
• Signal transduction within the cell leading to expression of genes for secondary metabolites.
• Genetic and epigenetic regulation of secondary metabolite biosynthesis.
• The significance of cellular localization of secondary metabolic pathways and their integration with primary metabolism.
• Secretion of secondary metabolites involving membrane-bound transporters and vesicular transport including extracellular vesicles.


Keywords: filamentous fungi, secondary metabolites, biosynthesis, signaling factors, secondary metabolite secretion


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Filamentous fungi impressively produce a large inventory of small bioactive molecules known as secondary metabolites. Secondary metabolites are often only made under certain environmental conditions and in response to particular stimuli, both biotic and abiotic. These environmental cues are recognized and transmitted within fungal cells resulting in the conditional expression of the genes and proteins involved in the biosynthesis of secondary metabolites. These biosynthetic pathways and the metabolites themselves can be confined to particular organelles within the cell allowing both for efficient biosynthesis and facilitated secretion of these small molecules.

This Research Topic will highlight current research on signal recognition, signal transduction, and regulation of metabolite expression. Also to be considered will be cellular compartmentalization of secondary metabolic pathways and secretion mechanisms by which metabolites are transported outside the cell.

We particularly welcome manuscripts that address:
• Signaling factors and signal recognition triggering secondary metabolite synthesis.
• Signal transduction within the cell leading to expression of genes for secondary metabolites.
• Genetic and epigenetic regulation of secondary metabolite biosynthesis.
• The significance of cellular localization of secondary metabolic pathways and their integration with primary metabolism.
• Secretion of secondary metabolites involving membrane-bound transporters and vesicular transport including extracellular vesicles.


Keywords: filamentous fungi, secondary metabolites, biosynthesis, signaling factors, secondary metabolite secretion


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

26 February 2021 Abstract
20 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

26 February 2021 Abstract
20 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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