About this Research Topic
The biological process of aging impacts almost all tissue function. One of the major concerns with age-related tissue function declines is the increased susceptibility to infections and resulting mortality. Virus infection including COVID-19 is one of the top ten killers of older adults in the world, with the oldest being most at risk. Aging impacts the immune system in many ways. Cells of the innate and adaptive arms exhibit altered phenotypes, along with diminished and dysregulated responses, as demonstrated in both human and mouse studies.
Until now, few mechanism-based interventions were available to improve immune responses to virus infection and resulting frailty in older adults. Emerging evidence suggests that retarding the fundamental aging process will simultaneously alleviate a range of age-related diseases and tissue dysfunction, which is now referred to as the Geroscience Hypothesis. Due to the high prevalence and uniquely complex nature of the impaired immune system in aging, the geroscience-guided approach, by targeting the whole aging process, might be beneficial for improving the immune response to various infection.
So far, a number of interventions have been indicated to delay the fundamental aging process including metformin, rapamycin, and senolytics. However, the effects of these interventions on immune function in aged subjects are still not fully known. With this Research Topic, we are interested in collecting the research investigating the effects (beneficial or harmful) of these known or novel geroscience-guided approaches on immune systems in aging. We are also interested in the research examining how the immune system contributes to the whole aging process.
Keywords: Aging, geroscience hypothesis, immune system, infection, senescence
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.