About this Research Topic
Membrane traffic regulates multiple cellular functions in the nervous system. Recently, accumulating evidence suggests that alteration in membrane traffic is involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Evidently, the generation of β-amyloid protein (Aβ), the component of AD pathology, is mediated by endocytosis of its precursor protein, and world-wide genome wide association studies (GWASs) have identified several endocytosis-related genes as risk factors for AD and PD. Moreover, several recent findings have shown that aging can alter functions of axonal transport motor proteins, which regulate endosome/lysosome trafficking, and age-related dysfunction in membrane traffic can cause neurodegeneration. These findings suggest that alteration in membrane traffic would be one of the causative factors for age-dependent neurodegenerative disorders. Hence, it is important to clarify the relationship of membrane traffic with the pathogenesis of age-related neurodegenerative disorders.
Although several studies focused on AD- or PD-related risk genes, there are a number of factors which can affect membrane traffic. Importantly, most patients do not have risk variants, suggesting that not only genetic factors alter membrane traffic in the nervous system. For example, alteration in lipid metabolism can also disrupt endosome trafficking. Thus, it is also necessary to understand the molecular mechanism of membrane traffic in the nervous system, and understand its relationship with brain aging.
In this Research Topic, we would like to share the findings on the relationship of membrane traffic with brain aging and age-related neurodegenerative diseases. We pursue Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Trial, Case Report and Opinion articles that cover, but are not limited to:
• Importance of membrane traffic in neurodegenerative diseases.
• Abnormal inflammatory responses by glial cells caused by alterations in receptor-mediated endocytosis.
• Dysregulation of neurotransmitter release in neurodegenerative diseases.
• Age-related changes in membrane traffic of the central or peripheral nervous system.
• Dysfunction in the interconnection of neural cells with the peripheral system, such as neurodegenerative disease-associated alterations in neuromuscular junctions or blood brain barrier.
Keywords: Membrane Traffic, Endocytosis, Exocytosis, Axonal Transport, Neurodegenerative Disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.