About this Research Topic
Intermediate filaments (IF) form a continuous and complex network that exerts a critical role in linking the contractile elements and organelles together and connects them to the sarcolemma in muscle tissues. By the interaction with two other major types of cytoskeletal networks, actin and microtubules filaments, IFs provide primarily a structural support in the maintenance of cell shape and architecture by resisting tensile and compressive forces. They further exert a role in cell and tissue homeostasis through their involvement in different biological processes, including mechanotransduction, signalization, organelle biogenesis and/or positioning, vesicle trafficking, apoptosis and gene expression. Therefore, IF proteins play a role in the preservation of muscle integrity and muscle contractility. Functional alteration of IF proteins in muscle is often linked to the onset of diverse diseases such as myopathies, cardiomyopathies and smooth muscle dysfunction syndrome.
Although the importance of IF proteins in muscle development, physiology and their involvement in the aetiology of several muscle pathologies are established, cellular and molecular pathomechanisms of IF protein mutations are not well deciphered. The present Research Topic aims at improving the knowledge concerning the role of IF proteins in the onset and progression of disorders affecting either the striated or the smooth muscle tissue, as well as basic aspects such as the regulation of dynamic structural organization of IFs, IF’s interactome and protein homeostasis.
In this Research Topic, we intend to deepen the knowledge concerning the role of IF proteins in muscle physiology with a special reference on the cellular and molecular pathomechanisms involving the onset and/or progression of diseases such as myopathies, cardiomyopathies and smooth muscle dysfunction syndrome. Original research and review articles dealing with following physiological related aspects of IFs: mechanotransduction, signaling pathway, calcium homeostasis, energy metabolism, protein homeostasis, stem cell differentiation, interactome and post-translational modification, are welcome. This Research Topic aspires to collect research focused on myopathic disorders in humans and related animal models of muscular dystrophies as well as those observed in animals including livestock and poultry in order to provide novel insights on the role of IF proteins in the occurrence and progressive pathology associated with these conditions.
Keywords: intermediate filament, muscle physiology, myopathy, cardiomyopathy, smooth muscle dysfunction
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