About this Research Topic
In this Research Topic, we would like to focus on the classical and the recently developed applications of immunoelectron microscopical techniques, to show that all are totally objective approaches that escape any conjecture as to where signalling molecules are localized. Actually, immunoelectron microscopy has opened up new opportunities to examine the brain at a level of detail never previously attained.
All article types accepted by Frontiers in Neuroanatomy are welcome for submission, including original research, reviews, brief research reports or commentary publications, that clarify conceptual or application aspects of subcellular localization of proteins in the brain. Some of these articles will be written by renowned laboratories working on immunoelectron microscopy, many of them the laboratories responsible of recent developments and innovations. Given the relatively narrow background and the advantages and disadvantages inherent to the different techniques, we are sure that readers can obtain useful information to design and proceed with the most appropriate approach in their own projects.
Subjects include but are not limited to:
• Pre-embedding techniques
• Post-embedding techniques
• FIB/SEM and immunoFIB/SEM
Keywords: Electron Microscopy, Pre-embedding, post-embedding, freeze-fracture, FIB/SEM, Synapse
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.