About this Research Topic
The cardiopulmonary system is critical for delivering oxygen, nutrients, hormones, and other important substances to cells/organs in the body, and its disorders are highly complicated and recognized as life-threatening diseases. Non-coding RNAs (ncRNAs) can be small (such as microRNAs 18 – 22 nt in length), and also long (more than 200 nt in length). ncRNAs are now considered as an essential regulator for the various status of cardiopulmonary diseases. Recent studies have demonstrated that ncRNAs can be identified in extracellular space and diverse body fluids. Moreover, emerging evidence suggests that extracellular ncRNAs play an important role in various physiological processes including immune response, vascular functions, tumorigenesis, epigenetic modifications, and cell transplantation as well as metabolism via intercellular communications.
However, it has not been clearly suggested or demonstrated what types of ncRNAs are secreted from cells, diffused into our body, and transported to specific cell types to have biological/physiological functions in the cardiopulmonary system. This question is fundamental to develop novel biomarkers and potential clinical applications for cardiopulmonary diseases. Therefore, validated experimental models or well-organized review articles on this topic will reveal an advancement of our knowledge on the extracellular ncRNAs in physiological and pathological conditions.
This Research Topic aims to extend our understanding of the extracellular ncRNAs in the cardiopulmonary system and disease status. The areas to be covered include, but are not limited to, the following:
• Physiological functions of extracellular ncRNAs in cardiopulmonary diseases
• Diagnostic potential of extracellular ncRNAs in cardiopulmonary diseases
• Therapeutic potential of extracellular ncRNAs in cardiopulmonary diseases
Keywords: cardiopulmonary diseases, extracellular non-coding RNAs, microRNAs, long non-coding RNAs
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