Research Topic

Comorbidities Associated with Endometriosis and the Impact of the Environment

About this Research Topic

Endometriosis is a gynecological disorder dependent on estrogen for growth that causes consider-able chronic pelvic pain, pain during intercourse, and is a major cause of infertility. This disorder affects 6% - 10% of reproductive age women, but can be as high as 35-50% in women experiencing pelvic pain and/or infertility. Robust epidemiologic data demonstrate a clear association between endometriosis, reproductive risk factors, inflammation, increased cardiovascular disease (CVD) risk, increased ovarian cancer risk, and increased risk of autoimmune disorders. Findings also implicate environmental endocrine disruptors may both cause and exacerbate this disease. The estrogen dependency and associated risks in women with endometriosis creates a conundrum: estrogen expo-sure is often considered protective for women, but estrogen suppression (the standard of care from a clinical standpoint), may be beneficial for reducing inflammatory signaling and lesion proliferation. However, not treating disease and hormone suppression lead to other associated comorbidities.

This Research Topic will tackle the complex disorder that is endometriosis and will do so from basic science and clinical perspectives. The goal of this Research Topic will be to address the importance of understanding the onset of endometriosis as a chronic systemic inflammatory disease that can be exacerbated by environmental exposures.

We would like contributors to address the following themes in their contributions:
- cardiovascular implications of endometriosis
- immunotoxicants and endocrine disrupting chemicals and their effect on the normal uterus
- pathophysiology of infertility, PCOS (polycystic ovarian syndrome) and other diseases linked or caused by endometriosis

We would like to acknowledge Dr. Valerie Flores has acted as coordinator and has contributed to the preparation of the proposal for this Research Topic.

Topic Editor Tanya Petrossian is the founder and CEO of EndoCyclic Therapeutics, a company working on developing a non-hormonal therapeutic for endometriosis. The other Topic Editors declare no competing interests with regard to the Research Topic subject.


Keywords: Endometriosis, immune, cardiovascular, toxicants, comorbidity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Endometriosis is a gynecological disorder dependent on estrogen for growth that causes consider-able chronic pelvic pain, pain during intercourse, and is a major cause of infertility. This disorder affects 6% - 10% of reproductive age women, but can be as high as 35-50% in women experiencing pelvic pain and/or infertility. Robust epidemiologic data demonstrate a clear association between endometriosis, reproductive risk factors, inflammation, increased cardiovascular disease (CVD) risk, increased ovarian cancer risk, and increased risk of autoimmune disorders. Findings also implicate environmental endocrine disruptors may both cause and exacerbate this disease. The estrogen dependency and associated risks in women with endometriosis creates a conundrum: estrogen expo-sure is often considered protective for women, but estrogen suppression (the standard of care from a clinical standpoint), may be beneficial for reducing inflammatory signaling and lesion proliferation. However, not treating disease and hormone suppression lead to other associated comorbidities.

This Research Topic will tackle the complex disorder that is endometriosis and will do so from basic science and clinical perspectives. The goal of this Research Topic will be to address the importance of understanding the onset of endometriosis as a chronic systemic inflammatory disease that can be exacerbated by environmental exposures.

We would like contributors to address the following themes in their contributions:
- cardiovascular implications of endometriosis
- immunotoxicants and endocrine disrupting chemicals and their effect on the normal uterus
- pathophysiology of infertility, PCOS (polycystic ovarian syndrome) and other diseases linked or caused by endometriosis

We would like to acknowledge Dr. Valerie Flores has acted as coordinator and has contributed to the preparation of the proposal for this Research Topic.

Topic Editor Tanya Petrossian is the founder and CEO of EndoCyclic Therapeutics, a company working on developing a non-hormonal therapeutic for endometriosis. The other Topic Editors declare no competing interests with regard to the Research Topic subject.


Keywords: Endometriosis, immune, cardiovascular, toxicants, comorbidity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

31 March 2021 Abstract
30 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

31 March 2021 Abstract
30 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..