Research Topic

Stimuli-Responsive Hybrid Nanoconstructs Based on Macrocycles for Biomedical Application

About this Research Topic

Hybrid nanoconstructs based on macrocycles is a widely investigated research area ranging from chemistry to material science. In the field of nanomaterials for biomedical applications, recent developments concern single molecule- to multi-stimuli-driven supramolecular assemblies leading from single- to multimodal therapeutic and diagnostic effects. Macrocyclic nanoconstructs take shape by self- or inter-module assembly of molecules, polymeric components and/or inorganic nanomaterials. Their features for biomedical performance can be generated by physicochemical inducement, including light, pH, ionic strength and temperature changes, redox, enzyme, magnetic or sono-chemical cues which act to produce i.e. optimized payload release, morphological interconversion, microtubular aggregation, and/or intra and inter-cellular communication.

In this Research Topic we would like to provide an overview of novel stimuli-responsive nanoplatforms composed by macrocycles combined with functional molecules such as polymers, metal nanoparticles, natural compounds, biomolecules, drugs, through supramolecular or covalent linkages. Manuscripts on nanoconstructs based on cyclodextrins, porphyrinoids, curcubiturils, calixarenes, crown ethers, hollow graphenes, etc., alone or coupled with a therapeutic or diagnostic agents that demonstrate a dynamic/responsive behavior by external or endogenous stimuli (light, pH, ionic strength, temperature, redox, enzyme, magnetic, sono-chemical etc.) will be very welcome. The manuscripts should have a strong chemical insight, and it is highly desirable that they encompass proofs of concept on bio-application of the proposed nanoplatform such as cell internalization, bio-compatibility, stability in biologically relevant media or biosensing .

The aim of this Research Topic is to aggregate novel chemical research disseminating high value advances on stimuli-responsive nanoconstructs based on macrocycles or macromolecules modified with a macrocyclic molecules by covalent or supramolecular strategy. We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:

• Assembly or Disassembly of macrocyclic platforms for biomedical strategies (nanoassemblies, nanogels or hydrogels)
• Nanoplatforms based on macrocycles with cues triggering therapeutic, diagnostic or biosensing response (phototherapies, drug monitoring in cells, sensing of body-toxic)
• Design and development of novel Inorganic nanoconstructs ( i.e. plasmonic or magnetic) with potential in therapy, bioimaging and biosensing
• pH, ionic strength or redox responsive nanoconstructs for drug delivery or release
• Enzyme- stimulated nanoconstructs
• New tools and strategies for characterizing the dynamics, morphology, and behavior of nanoconstructs responsive to endogenous and/or exogenous stimuli


Keywords: Macrocycles, Stimuli-responsive nanoplatform, self-assembly, dis-assembly, drug release, biosensing


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Hybrid nanoconstructs based on macrocycles is a widely investigated research area ranging from chemistry to material science. In the field of nanomaterials for biomedical applications, recent developments concern single molecule- to multi-stimuli-driven supramolecular assemblies leading from single- to multimodal therapeutic and diagnostic effects. Macrocyclic nanoconstructs take shape by self- or inter-module assembly of molecules, polymeric components and/or inorganic nanomaterials. Their features for biomedical performance can be generated by physicochemical inducement, including light, pH, ionic strength and temperature changes, redox, enzyme, magnetic or sono-chemical cues which act to produce i.e. optimized payload release, morphological interconversion, microtubular aggregation, and/or intra and inter-cellular communication.

In this Research Topic we would like to provide an overview of novel stimuli-responsive nanoplatforms composed by macrocycles combined with functional molecules such as polymers, metal nanoparticles, natural compounds, biomolecules, drugs, through supramolecular or covalent linkages. Manuscripts on nanoconstructs based on cyclodextrins, porphyrinoids, curcubiturils, calixarenes, crown ethers, hollow graphenes, etc., alone or coupled with a therapeutic or diagnostic agents that demonstrate a dynamic/responsive behavior by external or endogenous stimuli (light, pH, ionic strength, temperature, redox, enzyme, magnetic, sono-chemical etc.) will be very welcome. The manuscripts should have a strong chemical insight, and it is highly desirable that they encompass proofs of concept on bio-application of the proposed nanoplatform such as cell internalization, bio-compatibility, stability in biologically relevant media or biosensing .

The aim of this Research Topic is to aggregate novel chemical research disseminating high value advances on stimuli-responsive nanoconstructs based on macrocycles or macromolecules modified with a macrocyclic molecules by covalent or supramolecular strategy. We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:

• Assembly or Disassembly of macrocyclic platforms for biomedical strategies (nanoassemblies, nanogels or hydrogels)
• Nanoplatforms based on macrocycles with cues triggering therapeutic, diagnostic or biosensing response (phototherapies, drug monitoring in cells, sensing of body-toxic)
• Design and development of novel Inorganic nanoconstructs ( i.e. plasmonic or magnetic) with potential in therapy, bioimaging and biosensing
• pH, ionic strength or redox responsive nanoconstructs for drug delivery or release
• Enzyme- stimulated nanoconstructs
• New tools and strategies for characterizing the dynamics, morphology, and behavior of nanoconstructs responsive to endogenous and/or exogenous stimuli


Keywords: Macrocycles, Stimuli-responsive nanoplatform, self-assembly, dis-assembly, drug release, biosensing


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

29 January 2021 Abstract
28 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

29 January 2021 Abstract
28 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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