Research Topic

Biological Basis and Therapeutics of Behavioral and Psychological Symptoms of Dementia

About this Research Topic

An estimated 40 million people, mostly older than 60 years, have dementia worldwide, and this number is expected to increase significantly in the next decades. Despite ongoing advances in the understanding of the pathogenesis of AD and related dementias, no treatment available can prevent or delay the cognitive decline that characterizes the condition.

Besides cognitive impairment, nearly all patients with dementia present neuropsychiatric symptoms, also called behavioral and psychological symptoms of dementia (BPSD). BPSD have been associated with negative outcomes in dementia, including decrease of patient and caregiver quality of life, increased risk of institutionalization, higher costs and risk of mortality.
The expression ‘BPSD’ is an umbrella expression that encompasses different types of behavioral problems, such as agitation, apathy, delusion, insomnia, among others. Despite heterogeneous clinical presentations, the literature on BPSD usually does not address the specificities of individual syndromes, disregarding their different pathophysiological basis and therapeutics.

This Research Topic aims at dissecting the biological basis of different BPSD (apathy vs. depression vs. psychosis vs. aggression, etc.), including studies with imaging, genetics, biochemical, among other techniques that might inform about emerging therapeutic strategies. .

We welcome Original Research, Review, Brief Research Report, Case Report, Clinical Trial, Community Case Study, Data Report, General Commentary, Mini Review studies on the following subtopics:

• Imaging, genetics, biochemical and novel techniques informing on therapeutic strategies for BPSD;

• Studies on individual syndromes and clinical presentations of BPSD;

• Pharmacological and non-pharmacological (with special interest on neuromodulation) approaches to treat BPSD are highly encouraged;

• Studies on rare BPSD and preliminary interventions.


Keywords: BPSD, behavioral, dementia, AD, aging, cognitive decline


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

An estimated 40 million people, mostly older than 60 years, have dementia worldwide, and this number is expected to increase significantly in the next decades. Despite ongoing advances in the understanding of the pathogenesis of AD and related dementias, no treatment available can prevent or delay the cognitive decline that characterizes the condition.

Besides cognitive impairment, nearly all patients with dementia present neuropsychiatric symptoms, also called behavioral and psychological symptoms of dementia (BPSD). BPSD have been associated with negative outcomes in dementia, including decrease of patient and caregiver quality of life, increased risk of institutionalization, higher costs and risk of mortality.
The expression ‘BPSD’ is an umbrella expression that encompasses different types of behavioral problems, such as agitation, apathy, delusion, insomnia, among others. Despite heterogeneous clinical presentations, the literature on BPSD usually does not address the specificities of individual syndromes, disregarding their different pathophysiological basis and therapeutics.

This Research Topic aims at dissecting the biological basis of different BPSD (apathy vs. depression vs. psychosis vs. aggression, etc.), including studies with imaging, genetics, biochemical, among other techniques that might inform about emerging therapeutic strategies. .

We welcome Original Research, Review, Brief Research Report, Case Report, Clinical Trial, Community Case Study, Data Report, General Commentary, Mini Review studies on the following subtopics:

• Imaging, genetics, biochemical and novel techniques informing on therapeutic strategies for BPSD;

• Studies on individual syndromes and clinical presentations of BPSD;

• Pharmacological and non-pharmacological (with special interest on neuromodulation) approaches to treat BPSD are highly encouraged;

• Studies on rare BPSD and preliminary interventions.


Keywords: BPSD, behavioral, dementia, AD, aging, cognitive decline


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

17 February 2021 Abstract
17 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

17 February 2021 Abstract
17 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..