About this Research Topic
Dermatophytes are the cause of most common mycotic infections. They are transmitted quite easily, being often persistent and causing unpleasant symptoms that affect both physical and psychological health and compromising the quality of life.
Several factors like the innate immune system and genetics of the host or the ability of dermatophytes to invade the skin and its components through several lytic procedures may have role in the pathophysiology of the infection as well as the sensitivity of the fungi.
A number of dermatophytoses concern atypical presentations, relapses and treatment failures. Moreover, nowadays there is an increase in the reports of antifungal drug resistance in dermatophytes, mainly concerning Trichophyton spp.
Several factors can affect the diagnostic performance or the antifungal susceptibility testing (AST).
Although clinical successful treatment does not always correlate with the MIC, there is a need to
broadly implement and facilitate the methodology of AST in dermatophytes.
The antifungal susceptibility testing can provide an objective index that, combined with other information, could serve to obtain effective therapeutic options, minimal toxicity, prevent emerging resistance and decrease the cost of treatment. Up to now, there were not broadly used or commercialized and standardized techniques concerning AST in dermatophytes. Moreover, the proposed methodologies were often laborious for the everyday routine, resulting in the existence of only sparse information on the susceptibility patterns.
However, several methodological approaches, together with the recently released method by the EUCAST have to be tested and broadly implemented in order to shape the susceptibility profile of dermatophytes and to facilitate appropriate treatment.
This Research Topic focuses on studies (original research, reviews or mini reviews, methods,
perspectives, etc.) that investigate and discuss:
the possible role of the host mechanisms on the sensitivity and action of dermatophytes
the invading action and ways of the dermatophytes and how these factors influence their virulence or increase their resistance
molecular methods for identification and new taxonomical changes
the possible role of the antifungal treatment on the invading/lytic action of dermatophytes
the action of several antifungal drugs, as well as other alternative substances on dermatophytes
the susceptibility testing of dermatophytes and its role in the choose of appropriate treatment
the alternative methodologies that could facilitate the susceptibility testing
the comparative studies between different methods of AST
the performance characteristics as well as the quality control results of the methods used for the AST of dermatophytes
Keywords: : Dermatophytes, sensitivity, susceptibility testing, clinical outcome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.